Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer: A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE
| العنوان: | Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer: A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE |
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| المؤلفون: | Lucia Fratino, A Latorre, Antonio Rinaldi, Zaira Coccorullo, Palma Fedele, Salvatore Spazzapan, Vito Lorusso, Lazzaro Repetto, Ermenegildo Arnoldi, Laura Biganzoli, Mimma Raffaele, L. Petrucelli, Saverio Cinieri, Mariangela Ciccarese, Giovanna Campanella, Caterina Accettura, Luigi Coltelli, Salvatore Pisconti, Silvana Leo, Cosimo Brunetti, Marina Elena Cazzaniga |
| المساهمون: | Leo, S, Arnoldi, E, Repetto, L, Coccorullo, Z, Cinieri, S, Fedele, P, Cazzaniga, M, Lorusso, V, Latorre, A, Campanella, G, Ciccarese, M, Accettura, C, Pisconti, S, Rinaldi, A, Brunetti, C, Raffaele, M, Coltelli, L, Spazzapan, S, Fratino, L, Petrucelli, L, Biganzoli, L |
| المصدر: | The Oncologist. 24:e232-e240 |
| بيانات النشر: | Oxford University Press (OUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, Health-related quality of life, Antineoplastic Agents, Breast Neoplasms, Comprehensive geriatric assessment, 03 medical and health sciences, chemistry.chemical_compound, Elderly, 0302 clinical medicine, Quality of life, Internal medicine, Breast Cancer, Activities of Daily Living, Clinical endpoint, medicine, Humans, Prospective Studies, Furans, Geriatric Assessment, Aged, Aged, 80 and over, business.industry, Eribulin mesylate, Ketones, Metastatic breast cancer, medicine.disease, Tubulin Modulators, Discontinuation, Treatment Outcome, 030104 developmental biology, Italy, Oncology, chemistry, Tolerability, Geriatric oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, Geriatric Depression Scale, Neoplasm Recurrence, Local, business, Follow-Up Studies, Eribulin |
| الوصف: | Background Metastatic breast cancer (MBC) is highly prevalent in middle-aged or elderly patients. Eribulin is a nontaxane microtubule inhibitor, approved for the treatment of pretreated MBC. This multicentric study (sponsored by GIOGer, Italian Group for Geriatric Oncology) was designed to assess the efficacy and tolerability of eribulin, according to parameters usually used in geriatric oncology. Subjects, materials, and methods An observational study was conducted on 50 consecutive elderly patients with MBC. The primary endpoint was to evaluate the change in items score of comprehensive geriatric assessment (CGA) and health-related quality of life (HRQL). Italian versions of the CGA and HRQL questionnaires were administered at baseline, before the third and fifth cycles, and then every three cycles until treatment discontinuation. Secondary endpoints were efficacy and safety. Results Overall, both EQ-5D scores and EQ-5D-3 L visual analogic scale did not significantly change from baseline; the percentage of subjects without problems doing usual activities tended to decrease during treatment (p for linear trend .018), and the percentage of patients with minor problems performing usual activities tended to increase (p for linear trend.012). Among CGA items, Instrumental Activities of Daily Living tended to decrease during treatment and Geriatric Depression Scale tended to increase. After 12 months follow-up, 24 patients (out of 47) showed clinical benefits; median progression-free survival was 4.49 months (2.10-10.33) and median OS was 7.31 months (3.70-14.03). The treatment was associated with mild toxicity. Conclusion Eribulin treatment preserved quality of life and geriatric parameters included in the CGA, except for instrumental functioning and geriatric depression, in elderly patients with MBC. Implications for practice A collaboration between oncologist and geriatric specialists is essential in the management of patients with metastatic breast cancer, who are frequently elderly or frail. The assessment of geriatric parameters in the decision-making process can contribute to direct toward the most appropriate therapeutic plan and preserve the quality of life of patients. Eribulin does not seem to affect quality of life or worsen the overall geriatric status; therefore, it can be considered a suitable option for elderly patients with metastatic breast cancer. |
| تدمد: | 1549-490X 1083-7159 |
| DOI: | 10.1634/theoncologist.2017-0676 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d663d8eba2a42bcea57c48ea5a7e6 https://doi.org/10.1634/theoncologist.2017-0676 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....277d663d8eba2a42bcea57c48ea5a7e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1549490X 10837159 |
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| DOI: | 10.1634/theoncologist.2017-0676 |