Cytokine expression in Treponema pallidum infection
| العنوان: | Cytokine expression in Treponema pallidum infection |
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| المؤلفون: | Carlos F. Caceres, Silver K. Vargas, Yael Rosenberg-Hasson, Jeffrey D. Klausner, Janet C. Siebert, Segundo R. Leon, Kelika A. Konda, Noah Kojima, Holden T. Maecker |
| المصدر: | Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-9 (2019) Journal of Translational Medicine |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_treatment, lcsh:Medicine, Transgender Persons, General Biochemistry, Genetics and Molecular Biology, Rapid plasma reagin, Serology, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Medicine, Humans, Syphilis, Treponema pallidum, Prospective cohort study, Cytokine, Treponema, biology, medicine.diagnostic_test, business.industry, Incidence, Research, lcsh:R, General Medicine, medicine.disease, biology.organism_classification, 3. Good health, Titer, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, Cytokines, Female, business, Treponema pallidum particle agglutination assay |
| الوصف: | Background Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the differentiation of active and treated syphilis. Methods We collected quarterly serum samples from participants at risk for incident syphilis in a prospective cohort study of men and male-to-female transgender women. We defined incident syphilis as a new RPR titer ≥ 1:8 or a fourfold increase from a prior RPR titer and a positive Treponema pallidum particle agglutination assay. We measured cytokine expression using a 63-multiplex bead-based Luminex assay (eBiosciences/Affymetrix, San Diego, California, USA). We used tertile bins and Chi square tests to identify differences in proportions of cytokines between samples from patients with active and treated syphilis. We constructed a network of cytokine profiles from those findings. We used R software (R version 3.4.1, R, Vienna, Austria) to fit models. Results We identified 20 pairs of cytokines (out of 1953 possible pairs) that differed between active and treated syphilis. From those, we identified three cytokine networks of interest: an Eotaxin–Rantes–Leptin network, a Mig-IL1ra-Trail-CD40L network, and an IL12p40-IL12p70 network. Conclusions Differences in cytokine profiles are present among men and male-to-female transgender women with active and treated syphilis. Cytokine assays may be a potentially useful tool for identifying active syphilis among patients with serologic syphilis reactivity. Electronic supplementary material The online version of this article (10.1186/s12967-019-1947-7) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1479-5876 |
| DOI: | 10.1186/s12967-019-1947-7 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276338159449e367d76333909115a3ff http://link.springer.com/article/10.1186/s12967-019-1947-7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....276338159449e367d76333909115a3ff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14795876 |
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| DOI: | 10.1186/s12967-019-1947-7 |