Cordycepin Inhibits Induction of Murine Leukovirus Production By 5-Iodo-2′-deoxyuridine
| العنوان: | Cordycepin Inhibits Induction of Murine Leukovirus Production By 5-Iodo-2′-deoxyuridine |
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| المؤلفون: | M. Paran, R. C. Ting, A. M. Wu, R. C. Gallo |
| المصدر: | Proceedings of the National Academy of Sciences. 69:3820-3824 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1972. |
| سنة النشر: | 1972 |
| مصطلحات موضوعية: | Adenosine, Multidisciplinary, Dactinomycin, Deoxyadenosines, Cordycepin, RNA, RNA-Directed DNA Polymerase, Biology, Deoxyuridine, Molecular biology, Virus, Cell Line, chemistry.chemical_compound, Cell killing, chemistry, Transcription (biology), Cell culture, Cephalothin, Cyclic AMP, medicine, Gammaretrovirus, Biological Sciences: Cell Biology, medicine.drug |
| الوصف: | Cordycepin (3′-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2′-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA. |
| تدمد: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.69.12.3820 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e78702ba53da077f6677ae0faca2b https://doi.org/10.1073/pnas.69.12.3820 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....274e78702ba53da077f6677ae0faca2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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| DOI: | 10.1073/pnas.69.12.3820 |