Surgical Management and Outcome of Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus
| العنوان: | Surgical Management and Outcome of Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus |
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| المؤلفون: | Tibor Flaskó, Zsolt Bacsó, Tamás Szerafin, Ben Thomas, Akos Berczi, Csaba Berczi |
| المصدر: | Urologia Internationalis. 99:267-271 |
| بيانات النشر: | S. Karger AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, medicine.medical_treatment, 030232 urology & nephrology, Kaplan-Meier Estimate, Nephrectomy, law.invention, 0302 clinical medicine, Risk Factors, law, Renal cell carcinoma, Elméleti orvostudományok, Thrombectomy, Aged, 80 and over, Venous Thrombosis, Cardiopulmonary Bypass, Orvostudományok, Middle Aged, Neoplastic Cells, Circulating, Kidney Neoplasms, Tumor Burden, Circulatory Arrest, Deep Hypothermia Induced, Treatment Outcome, medicine.vein, 030220 oncology & carcinogenesis, cardiovascular system, Female, Radiology, Adult, medicine.medical_specialty, Urology, Vena Cava, Inferior, Inferior vena cava, Disease-Free Survival, 03 medical and health sciences, medicine, Cardiopulmonary bypass, Humans, Thrombus, Carcinoma, Renal Cell, Aged, Neoplasm Staging, business.industry, Cancer, Histology, medicine.disease, Surgery, Tumor progression, Neoplasm Recurrence, Local, business |
| الوصف: | Introduction: The authors of this paper assessed the surgical management and outcome of renal cancers when tumor thrombus extended into the inferior vena cava (IVC). Methods: From 2000 to 2015, 46 radical nephrectomies were performed on patients with tumor thrombus in the IVC. The mean age of the patients was 60 ± 11 years. Radical nephrectomy and thrombectomies were performed in a single session. There were 18 level-IV, 23 level-III, and 5 level-II tumor thrombi. The operations were performed using cardiopulmonary bypass in 14 patients, while deep hypothermic cardiac arrest was carried out in 4 cases. Results: The mean size of the tumors was 9.4 ± 3.5 cm. Histology showed the tumor stages to be pT3b in 21cases, pT3c in 22, and pT4 in 3 patients. The mean follow-up period of the patients was 3.6 ± 3.0 years. During the follow-up period, local recurrence was observed in 7 patients, while distant metastases occurred in 8 cases. The median time to progression was 37 ± 27 months. The 5-year overall survival was 43.7%. Conclusions: Radical nephrectomy and thrombectomy provided reasonable long-term survival for patients with renal cancer and IVC thrombus. However, tumor progression was detected in 41.6%. The presence of tumor thrombus had a negative effect on tumor progression and survival. |
| وصف الملف: | application/pdf |
| تدمد: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000464108 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ddcc938f42198bd034405713bad300 https://doi.org/10.1159/000464108 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....26ddcc938f42198bd034405713bad300 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230399 00421138 |
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| DOI: | 10.1159/000464108 |