Humoral Hypercalcemia Complicating Adenocarcinoma of the Sigmoid Colon: Report of a Case
| العنوان: | Humoral Hypercalcemia Complicating Adenocarcinoma of the Sigmoid Colon: Report of a Case |
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| المؤلفون: | Yoshio Shirai, Jun Sakata, Katsuyoshi Hatakeyama, Toshifumi Wakai, Eiko Sakata, Go Hasegawa |
| المصدر: | Surgery Today. 35:692-695 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | musculoskeletal diseases, Oncology, medicine.medical_specialty, endocrine system diseases, Paraneoplastic Syndromes, Colorectal cancer, Adenocarcinoma, Gastroenterology, Surgical oncology, Internal medicine, medicine, Humans, Parathyroid hormone-related protein, Systemic chemotherapy, business.industry, Poorly differentiated, Disease progression, Parathyroid Hormone-Related Protein, Sigmoid colon, General Medicine, Middle Aged, medicine.disease, Sigmoid Neoplasms, medicine.anatomical_structure, Hypercalcemia, Female, Surgery, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Humoral hypercalcemia can arise from a variety of malignancies, but its association with primary colorectal carcinoma is rare, with only 20 such cases documented in the English-language literature to date. We report an additional case to clarify the clinicopathologic features of colorectal carcinoma with humoral hypercalcemia. A 54-year-old woman was admitted with symptomatic hypercalcemia of 14.2 mg/dl and multiple hepatic metastases, 2 years after resection of sigmoid colon cancer. The hypercalcemia was caused by the circulating parathyroid hormone-related peptide (PTHrP) produced by poorly differentiated adenocarcinoma in the liver. The PTHrP level on admission was 13.5 pmol/l. Despite systemic chemotherapy, the patient died of disease progression 3 weeks after the humoral hypercalcemia was diagnosed. A review of the 21 reported cases, including ours, suggests that colorectal carcinoma associated with humoral hypercalcemia is characterized by a poorly differentiated tumor with or without squamous or neuroendocrine features, distant metastases, and a dismal prognosis. |
| تدمد: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-004-2974-3 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269f287dfa47bedbcaac4efda011114d https://doi.org/10.1007/s00595-004-2974-3 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....269f287dfa47bedbcaac4efda011114d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14362813 09411291 |
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| DOI: | 10.1007/s00595-004-2974-3 |