Prenatal Isolated Ventricular Septal Defect May Not Be Associated with Trisomy 21
| العنوان: | Prenatal Isolated Ventricular Septal Defect May Not Be Associated with Trisomy 21 |
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| المؤلفون: | Ephrat Levy-Lahad, Daniel Terner, Sari Lieberman, Ori Shen, Benjamin Farber, Amnon Lahad |
| المصدر: | Journal of Clinical Medicine, Vol 3, Iss 2, Pp 432-439 (2014) Journal of Clinical Medicine; Volume 3; Issue 2; Pages: 432-439 Journal of Clinical Medicine |
| بيانات النشر: | MDPI AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Fetus, Pediatrics, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, prenatal diagnosis, Heart disease, business.industry, Pediatric cardiologist, lcsh:R, lcsh:Medicine, Prenatal diagnosis, General Medicine, medicine.disease, Screen test, congenital heart disease, Article, trisomy 21, Nuchal translucency, Genetic amniocentesis, ventriculoseptal defect, medicine, Trisomy, business |
| الوصف: | The aim of this study was to examine if isolated fetal ventricular septal defect (VSD) is associated with trisomy 21. One hundred twenty six cases with prenatal VSD diagnosed by a pediatric cardiologist were reviewed. Cases with known risk factors for congenital heart disease, the presence of other major anomalies, soft signs for trisomy 21 or a positive screen test for trisomy 21 were excluded. Ninety two cases formed the study group. None of the cases in the study group had trisomy 21. The upper limit of prevalence for trisomy 21 in isolated VSD is 3%. When prenatal VSD is not associated with other major anomalies, soft markers for trisomy 21 or a positive nuchal translucency or biochemical screen, a decision whether to perform genetic amniocentesis should be individualized. The currently unknown association between isolated VSD and microdeletions and microduplications should be considered when discussing this option. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26324956b35358457afc93fb14eede35 http://www.mdpi.com/2077-0383/3/2/432 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26324956b35358457afc93fb14eede35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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