Impaired Gastric Cancer Survival in Patients with Inflammatory Bowel Disease
| العنوان: | Impaired Gastric Cancer Survival in Patients with Inflammatory Bowel Disease |
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| المؤلفون: | Rob H.A. Verhoeven, Lauranne A A P Derikx, Marieke Pierik, Eemke L. Assendorp, Rachel S. van der Post, Tim van den Heuvel, Iris D. Nagtegaal, Lucy I H Overbeek, Dirk J. de Jong, Loes H C Nissen, Frank Hoentjen, Wietske Kievit |
| المساهمون: | CCA - Cancer Treatment and Quality of Life, CTC, MUMC+: MA Maag Darm Lever (9), Interne Geneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis, Promovendi NTM |
| المصدر: | Journal of gastrointestinal and liver diseases, 25(4), 431-440. Romanian Society of Gastroenterology Journal of Gastrointestinal and Liver Diseases, 25, 431-440 Journal of Gastrointestinal and Liver Diseases, 25, 4, pp. 431-440 Journal of Gastrointestinal and Liver Diseases, 25(4), 431-440. Romanian Society of Gastroenterology |
| بيانات النشر: | Romanian Society of Gastroenterology, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Time Factors, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Biopsy, Kaplan-Meier Estimate, Inflammatory bowel disease, Gastroenterology, 0302 clinical medicine, Crohn Disease, Risk Factors, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Odds Ratio, Registries, Age of Onset, Netherlands, education.field_of_study, Middle Aged, Prognosis, Ulcerative colitis, 030211 gastroenterology & hepatology, Female, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Immunosuppressive Agents, Adult, medicine.medical_specialty, Population, immunosuppressive therapy, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Risk Assessment, digestive system, inflammatory bowel diseases, 03 medical and health sciences, Stomach Neoplasms, Internal medicine, medicine, Humans, Risk factor, education, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Chi-Square Distribution, business.industry, gastric cancer, Cancer, Retrospective cohort study, medicine.disease, digestive system diseases, Cancer registry, 030104 developmental biology, Logistic Models, Multivariate Analysis, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], Colitis, Ulcerative, Age of onset, business |
| الوصف: | Background & Aims: Both chronic inflammation and reduced immunosurveillance contribute to malignancy development in inflammatory bowel disease (IBD). Previous literature suggests that especially Crohn’s disease patients are at an increased risk for developing gastric cancer (GC). This study aimed to identify risk factors for GC development in IBD and to compare the clinical characteristics of GC in IBD to those in the general population. Methods: We retrospectively searched the Dutch Pathology Database to identify all Dutch IBD patients with GC between January 2004 and December 2008. Two case-control studies were performed. I: to identify risk factors for GC in IBD, with controls from the IBD South Limburg (IBDSL) population-based cohort; and II: to compare GC disease course in IBD patients with the general population. General population data were obtained from the Eindhoven Cancer Registry (ECR). Results: We included 59 patients with IBD and GC (cases). Cases were significantly older at IBD diagnosis than IBDSL controls (median age 61 years versus 40; p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1841-8724 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255cc3e097c132beac441eb5cb0895ca https://cris.maastrichtuniversity.nl/en/publications/8471161f-3183-4b57-b27c-3a47650592c7 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....255cc3e097c132beac441eb5cb0895ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18418724 |
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