Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
| العنوان: | Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections |
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| المؤلفون: | Lola Brookes, Jennifer M. G. Shelton, Phillip Jervis, Thomas R. Sewell, Dana Kappel, Pria Ghosh, Emily Skelly, Matthew C. Fisher, Johanna Rhodes, Hannah M. Edwards |
| المساهمون: | Natural Environment Research Council [2006-2012], Wellcome Trust, Natural Environment Research Council (NERC), Medical Research Council (MRC) |
| المصدر: | Life, Vol 10, Iss 315, p 315 (2020) Life |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Life Sciences & Biomedicine - Other Topics, 0301 basic medicine, GEOMYCES-DESTRUCTANS, 030106 microbiology, VANCOUVER-ISLAND, Large population, Wildlife, Genomics, Review, Biology, Microbiology, General Biochemistry, Genetics and Molecular Biology, MAGNAPORTHE, emerging fungal pathogen, 03 medical and health sciences, Human health, BATRACHOCHYTRIUM-DENDROBATIDIS, PATHOGEN MYCOSPHAERELLA-GRAMINICOLA, Food supply, Human medicine, lcsh:Science, Ecology, Evolution, Behavior and Systematics, GENE-EXPRESSION, Science & Technology, Cross disciplinary, REAL-TIME, Paleontology, fungal-omics, Omics, Data science, POPULATION GENOMICS, cross-disciplinary, Biology and Microbiology, 030104 developmental biology, Health, Space and Planetary Science, CRYPTOCOCCUS-GATTII, lcsh:Q, Life Sciences & Biomedicine, RESISTANCE |
| الوصف: | Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future. |
| وصف الملف: | text |
| اللغة: | English |
| تدمد: | 2075-1729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f133c9791523a1d3da87c6f501a38d https://www.mdpi.com/2075-1729/10/12/315 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24f133c9791523a1d3da87c6f501a38d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20751729 |
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