Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes
| العنوان: | Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes |
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| المؤلفون: | Caitlin E. Paisley, Logan C. Meyer, Tomasz Kordula, Kabirullah Lutfy, Carmen Sato-Bigbee, Hope Richard, John W. Bigbee, Esraa Mohamed |
| المصدر: | Glia, vol 65, iss 12 Meyer, LC; Paisley, CE; Mohamed, E; Bigbee, JW; Kordula, T; Richard, H; et al.(2017). Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes.. Glia, 65(12), 2003-2023. doi: 10.1002/glia.23210. UC Office of the President: Tobacco-Related Disease Research Program. Retrieved from: http://www.escholarship.org/uc/item/2cr1c0zq |
| بيانات النشر: | eScholarship, University of California, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Amino Acid Transport System X-AG, brain development, Nociceptin Receptor, Rats, Sprague-Dawley, Mice, 0302 clinical medicine, Glutamate homeostasis, Receptors, Developmental, Enzyme Inhibitors, Cells, Cultured, Mice, Knockout, Neurons, Cultured, Glutamate receptor, Gene Expression Regulation, Developmental, Nociceptin receptor, medicine.anatomical_structure, Neurology, Opioid Peptides, glutamate transporters, Astrocyte, Signal Transduction, Cells, Knockout, Glutamic Acid, Opioid, Biology, Hydroxylamines, Aldehyde Dehydrogenase 1 Family, Article, GLAST, 03 medical and health sciences, Cellular and Molecular Neuroscience, Fetus, Glial Fibrillary Acidic Protein, medicine, nociceptin, Animals, Humans, Protein kinase B, PI3K/AKT/mTOR pathway, Neurology & Neurosurgery, astrocytes, Neurosciences, Retinal Dehydrogenase, Transporter, Newborn, Oligodendrocyte, Rats, 030104 developmental biology, Animals, Newborn, Gene Expression Regulation, Astrocytes, Receptors, Opioid, Sprague-Dawley, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Our previous results showed that oligodendrocyte development is regulated by both nociceptin and its G-protein coupled receptor, the nociceptin/orphanin FQ receptor (NOR). The present in vitro and in vivo findings show that nociceptin plays a crucial conserved role regulating the levels of the glutamate/aspartate transporter GLAST/EAAT1 in both human and rodent brain astrocytes. This nociceptin-mediated response takes place during a critical developmental window that coincides with the early stages of astrocyte maturation. GLAST/EAAT1 upregulation by nociceptin is mediated by NOR and the downstream participation of a complex signaling cascade that involves the interaction of several kinase systems, including PI-3K/AKT, mTOR, and JAK. Because GLAST is the main glutamate transporter during brain maturation, these novel findings suggest that nociceptin plays a crucial role in regulating the function of early astrocytes and their capacity to support glutamate homeostasis in the developing brain. |
| وصف الملف: | application/pdf |
| DOI: | 10.1002/glia.23210. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2486d1452099030a6f73939241e4e155 https://escholarship.org/uc/item/2cr1c0zq |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2486d1452099030a6f73939241e4e155 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1002/glia.23210. |
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