Added value of impact microindentation in the evaluation of bone fragility: a systematic review of the literature
| العنوان: | Added value of impact microindentation in the evaluation of bone fragility: a systematic review of the literature |
|---|---|
| المؤلفون: | F. Malgo, Elizabeth M. Winter, Manuela Schoeb, Natasha M. Appelman-Dijkstra, Neveen A. T. Hamdy |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, 11. FRONTIERS MEDIA SA Frontiers in Endocrinology, Vol 11 (2020) |
| بيانات النشر: | FRONTIERS MEDIA SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Fracture risk, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, fracture risk, Osteoporosis, osteoprobe, osteoporosis primary and secondary, 030209 endocrinology & metabolism, Bone fragility, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Bone and Bones, Specimen Handling, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Endocrinology, Absorptiometry, Photon, Bone Density, Predictive Value of Tests, Risk Factors, Added value, Medicine, Humans, Bone mineral, lcsh:RC648-665, business.industry, Gold standard, Biopsy, Needle, dual energy x-ray absorptiometry (DXA), medicine.disease, bone quality, Metabolic Bone Disorder, bone material strength index (BMSi), Bone Diseases, Metabolic, 030104 developmental biology, Equipment and Supplies, Physical therapy, Microtechnology, rare bone diseases, Secondary osteoporosis, Systematic Review, business, bone mineral density, Osteoporotic Fractures |
| الوصف: | The current gold standard for the diagnosis of osteoporosis and the prediction of fracture risk is the measurement of bone mineral density (BMD) using dual energy x-ray absorptiometry (DXA). A low BMD is clearly associated with increased fracture risk, but BMD is not the only determinant of bone strength, particularly in secondary osteoporosis and metabolic bone disorders in which components other than BMD are affected and DXA often underestimates true fracture risk. Material properties of bone which significantly contribute to bone strength have become evaluable in vivo with the impact microindentation (IMI) technique using the OsteoProbe (R) device. The question arises whether this new tool is of added value in the evaluation of bone fragility. To this effect, we conducted a systematic review of all clinical studies using IMI in vivo in humans also addressing practical aspects of the technique and differences in study design, which may impact outcome. Search data generated 38 studies showing that IMI can identify patients with primary osteoporosis and fractures, patients with secondary osteoporosis due to various underlying systemic disorders, and scarce longitudinal data also show that this tool can detect changes in bone material strength index (BMSi), following bone-modifying therapy including use of corticosteroids. However, this main outcome parameter was not always concordant between studies. This systematic review also identified a number of factors that impact on BMSi outcome. These include subject- and disease-related factors such as the relationship between BMSi and age, geographical region and the presence of fractures, and technique- and operator-related factors. Taken together, findings from this systematic review confirm the added value of IMI for the evaluation and follow-up of elements of bone fragility, particularly in secondary osteoporosis. Notwithstanding, the high variability of BMSi outcome between studies calls for age-dependent reference values, and for the harmonization of study protocols. Prospective multicenter trials using standard operating procedures are required to establish the value of IMI in the prediction of future fracture risk, before this technique is introduced in routine clinical practice. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24113b14baa4a578f7cbd06056d8a3c5 https://hdl.handle.net/1887/3185218 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24113b14baa4a578f7cbd06056d8a3c5 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |