Evaluating a decision tool for diagnosing diastolic dysfunction and estimation of left ventricular filling pressures in the presence of mitral annular calcium
| العنوان: | Evaluating a decision tool for diagnosing diastolic dysfunction and estimation of left ventricular filling pressures in the presence of mitral annular calcium |
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| المؤلفون: | Adedotun Ogunsua, Alison B. Chambers, John Dickey, Wen-Chih Wu, Philip Haines, Gerard P. Aurigemma |
| المصدر: | Echocardiography. 37:1757-1765 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Decision tool, Mitral annular calcification, Left heart catheterization, Diastole, 030204 cardiovascular system & hematology, Single Center, Ventricular Function, Left, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Ventricular Pressure, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Mean age, Middle Aged, Echocardiography, Doppler, Cardiology, Calcium, False positive rate, Cardiology and Cardiovascular Medicine, Ventricular filling, business |
| الوصف: | Objectives This study sought to evaluate a decision algorithm for the estimation of left ventricular filling pressure (LVFP) in patients with mitral annular calcification (MAC). Background In a single center study, Abudiab et al evaluated echocardiographic parameters to estimate LVFP in patients with MAC against invasive hemodynamic measurements and developed a decision algorithm which demonstrated high predictive accuracy. Methods Retrospectively, 55 patients (mean age 68.5 ± 11.5) with MAC and a left heart catheterization within 24 hours of an echocardiogram were identified. The decision algorithm was applied using echo data to classify patients as having normal or elevated LVFP which was then compared with the invasively obtained LVFP. Results The algorithm performed poorly at predicting pre-A LVFP as normal or high (P = .182). Accuracy for the algorithm was 0.59 [0.46, 0.72] (mean [95% CI]), sensitivity was 0.45 [0.28, 0.62], specificity was 0.73 [0.54, 0.86], false positive rate was 0.27 [0.14, 0.46], and false negative rate was 0.55 [0.38, 0.72]. E/A ratio, IVRT, and E/e'ratio showed no significant relationship to actual patient LVFP. Conclusions The Abudiab et al algorithm failed to demonstrate comparable sensitivity, specificity, and accuracy in our sample. Additional study is necessary to refine this tool prior to more widespread use in clinical practice. |
| تدمد: | 1540-8175 0742-2822 |
| DOI: | 10.1111/echo.14878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235488f4656d91f04475d0643c974837 https://doi.org/10.1111/echo.14878 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....235488f4656d91f04475d0643c974837 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408175 07422822 |
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| DOI: | 10.1111/echo.14878 |