The anti-obesity effect of starch in a whole grain-like structural form
| العنوان: | The anti-obesity effect of starch in a whole grain-like structural form |
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| المؤلفون: | Xufeng Wang, Kaiyun Luo, Genyi Zhang |
| المصدر: | Food & Function. 9:3755-3763 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Starch, Mice, Obese, White adipose tissue, Butyric acid, Mice, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Animals, Humans, PPAR alpha, Obesity, Whole Grains, Adipogenesis, biology, Lipogenesis, Lipid metabolism, General Medicine, Lipid Metabolism, Neuropeptide Y receptor, Mice, Inbred C57BL, Fatty acid synthase, 030104 developmental biology, Endocrinology, chemistry, biology.protein, Fermentation, Anti-Obesity Agents, Fatty Acid Synthases, Energy Metabolism, Sterol Regulatory Element Binding Protein 1, Food Science |
| الوصف: | Obesity is a risk factor for many chronic diseases, and the anti-obesity effect of starch in a whole grain-like structural form (WGLSF) prepared through co-gelation with oat β-glucan and alginate was studied using high-fat (HF) induced obese male C57BL/6J mice. In vitro human fecal fermentation of WGLSF-starch showed a slower rate of fermentation and a higher production of butyric acid (132.0 μmol per 50 mg sample) when compared to the physical mixture counterpart of starch, β-glucan, and alginate (PM) (110.5 μmol per 50 mg) or β-glucan itself (96.2 μmol per 50 mg). The body weight gain of obese mice fed with a HF-WGLSF diet was significantly reduced (42.0% lower than the HF group, 30.2% lower than the physical mixture) with decreased cell size in white adipose tissue and similar levels of serum lipid profiles to the control of the low-fat (LF) group. Western blotting experiments showed the down-regulated lipogenic transcription factor of SREBP-1c and fatty acid synthase (FAS), but the lipid-oxidation related transcription factors of peroxisome proliferator-activated receptor-α (PPAR-α) and phosphorylated AMP-activated protein kinase (p-AMPK) were up-regulated. Energy metabolism analysis revealed increased lipid-sourced energy expenditure with higher heat production and respiratory exchange ratios. Consistently, the expression of hypothalamic pro-opiomelanocortin (POMC), favoring energy expenditure, was increased significantly while the neuropeptide Y (NPY) was reduced. Thus, the increased energy expenditure stimulated by starch in a whole-grain-like structural form is responsible for the reduced body weight gain of obese mice fed with a high fat-based diet. |
| تدمد: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c8fo00602d |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234e91e230791d21d4a480f4a8e7ad5c https://doi.org/10.1039/c8fo00602d |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....234e91e230791d21d4a480f4a8e7ad5c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2042650X 20426496 |
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| DOI: | 10.1039/c8fo00602d |