التفاصيل البيبلوغرافية
العنوان:
Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M
المؤلفون:
Marco Bürger , Stephan A. Sieber , Christian Hedberg , Ingrid R. Vetter , Thomas Böttcher , Andreas Brockmeyer , Kristina Görmer , Frank J. Dekker , Herbert Waldmann , Gemma Triola , Marion Rusch , Tobias J. Zimmermann , Petra Janning
المساهمون:
Groningen Research Institute of Pharmacy, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB)
المصدر:
Angewandte Chemie-International Edition, 50(42), 9838-9842. WILEY-V C H VERLAG GMBH
بيانات النشر:
Wiley, 2011.
سنة النشر:
2011
مصطلحات موضوعية:
BETA-LACTONES , Proteome , Ras proteins , LIPID-MODIFIED PROTEINS , 010402 general chemistry , Proteomics , 01 natural sciences , Catalysis , Structure-Activity Relationship , 03 medical and health sciences , proteomics , CHEMISTRY , Propiolactone , Humans , Sulfones , Enzyme Inhibitors , IN-VIVO , 030304 developmental biology , 0303 health sciences , Molecular Structure , 010405 organic chemistry , Proteomic Profiling , Chemistry , acyl protein thioesterase , LOCALIZATION , General Medicine , General Chemistry , inhibition , 0104 chemical sciences , 3. Good health , DEPALMITOYLATION , Palmitoyl-CoA Hydrolase , Biochemistry , Identification (biology) , Acyl-Protein Thioesterase 1 , Thiolester Hydrolases , Fatty Acid Synthases , Signal transduction , signal transduction , Palmostatin B , HeLa Cells
الوصف:
Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.
تدمد:
1433-7851
DOI:
10.1002/anie.201102967
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231890fe4bbf02ed208840cb3ecea157 https://doi.org/10.1002/anie.201102967
Rights:
RESTRICTED
رقم الانضمام:
edsair.doi.dedup.....231890fe4bbf02ed208840cb3ecea157
قاعدة البيانات:
OpenAIRE