Clinical application of genetics to guide prevention and treatment of oral diseases
| العنوان: | Clinical application of genetics to guide prevention and treatment of oral diseases |
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| المؤلفون: | P.J. Polverini, K.S. Kornman |
| المصدر: | Clinical Genetics |
| بيانات النشر: | Blackwell Publishing Ltd, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Oncology, Genetic Markers, alpha Karyopherins, medicine.medical_specialty, Reviews, Genome-wide association study, Dental Caries, Diabetes mellitus, Internal medicine, medicine, Aggressive periodontitis, Humans, genetics, Precision Medicine, Periodontitis, Genetics (clinical), Genetic association, caries, business.industry, CDKN2BAS, Genetic Variation, oral cancer, medicine.disease, Chronic periodontitis, Head and Neck Neoplasms, Immunology, Carcinoma, Squamous Cell, Mouth Neoplasms, Muramidase, RNA, Long Noncoding, Personalized medicine, business, Cell Adhesion Molecules, Genome-Wide Association Study, Interleukin-1 |
| الوصف: | Dental care costs in the United States exceed $100 billion annually. Personalized medicine efforts in dentistry are driven by potentially compelling clinical utility and cost-effectiveness prospects in the major diseases of periodontitis, caries, and oral cancers. This review discusses progress and challenges identifying genetic markers and showing clinical utility in dentistry. Genome-wide association studies (GWAS) of chronic periodontitis (CP) identified no significant variants, but CDKN2BAS variants on chromosome 9 were significantly associated with aggressive periodontitis. Stratifying patients by interleukin (IL)-1 gene variants, smoking and diabetes differentiated CP prevention outcomes. Dental caries' GWAS identified significant signals in LYZL2, AJAp1, and KPNA4; and efforts are ongoing to identify genetic factors for multiple caries phenotypes. Trials of molecularly targeted therapies are in progress for oral, head, and neck squamous cell carcinomas (OHNSCC) and results have been promising but limited in their effectiveness. Current opportunities and challenges for molecular targeting for OHNSCC are discussed. |
| اللغة: | English |
| تدمد: | 1399-0004 0009-9163 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d6f2906a63d87a7b93d153aab2b153 http://europepmc.org/articles/PMC4233973 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....22d6f2906a63d87a7b93d153aab2b153 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13990004 00099163 |
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