Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy
| العنوان: | Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy |
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| المؤلفون: | Adrienne Verhoef, Bernard Maillere, Cezmi A. Akdis, M. D. Tarzi, S. Klunker, A. B. Kay, Catherine Texier, S. O. Stapel, Mark Larché |
| المساهمون: | Imperial College London (Department of Allergy εt Clinical Immunology), Faculty of Medicine-National Heart εt Lung Institute, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Commissariat a l'Energie Atomique-Saclay (Protein Engineering and Research Department), Commissariat à l'Energie Atomique-Saclay |
| المصدر: | Clinical and Experimental Allergy Clinical and Experimental Allergy, Wiley, 2006, 36 (4), pp.465-74. ⟨10.1111/j.1365-2222.2006.02469.x⟩ |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, MESH: Signal Transduction, MESH: Drug Hypersensitivity, MESH: Interleukin-13, MESH: Interleukin-10, Allergy, medicine.medical_treatment, Epitopes, T-Lymphocyte, Suppressor of Cytokine Signaling Proteins, Antigenic determinant, Signal transduction, Epitope, Interleukin 10, MESH: Bee Venoms, 0302 clinical medicine, Immunology and Allergy, MESH: Treatment Outcome, MESH: Immunoglobulin G, MESH: Cytokines, 0303 health sciences, Interleukin-13, biology, MESH: Peptides, Forkhead Transcription Factors, MESH: Transcription Factors, Immunohistochemistry, MESH: Suppressor of Cytokine Signaling Proteins, MESH: Gene Expression Regulation, Interleukin-10, 3. Good health, Bee Venoms, MESH: Leukocytes, Mononuclear, Treatment Outcome, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Cytokine, medicine.anatomical_structure, Cytokines, MESH: Immunotherapy, Active, MESH: Cell Division, Female, MESH: Phospholipases A, Immunotherapy, Antibody, Cell Division, Human, Adult, Injections, Intradermal, T cell, Immunology, Immunopathology, Suppressor of cytokine signalling, Phospholipases A, Drug Hypersensitivity, MESH: Epitopes, T-Lymphocyte, 03 medical and health sciences, MESH: Forkhead Transcription Factors, Suppressor gene, medicine, Humans, 030304 developmental biology, MESH: Injections, Intradermal, MESH: Humans, Immunotherapy, Active, MESH: Adult, MESH: Immunohistochemistry, HLA-DR Antigens, MESH: HLA-DR Antigens, MESH: Male, Treatment, Gene Expression Regulation, T-Lymphocyte, Suppressor of Cytokine Signaling 3 Protein, Immunoglobulin G, Anergy, Leukocytes, Mononuclear, Peptide vaccine, biology.protein, Gene expression, Transcription factor, Peptides, Tolerance, MESH: Female, Transcription Factors, 030215 immunology |
| الوصف: | International audience; BACKGROUND: Allergen-derived (T cell epitope) peptides may be safer for immunotherapy than native allergen, as they do not cross-link immunoglobulin (Ig)E. However, HLA polymorphism results in multiple potential epitopes. Synthetic peptides of phospholipase (PL) A(2) were selected for a peptide vaccine, on the basis of binding affinity for commonly expressed HLA-DR molecules. OBJECTIVE: To evaluate treatment with an HLA-DR-based PLA(2) peptide vaccine in subjects with mild honeybee allergy in an open, controlled study. METHODS: Twelve volunteers with allergy to bee venom received nine intradermal injections of PLA(2) peptides, with six untreated subjects serving as controls. Outcome was assessed by the size of the late-phase cutaneous reaction to allergen, peripheral blood mononuclear cell (PBMC) proliferation, cytokine release, and expression of genes associated with immune regulation. RESULTS: Subjects receiving peptides showed a decrease in the magnitude of the late-phase cutaneous reaction to bee venom compared with controls (P=0.03). The proliferation of venom-stimulated PBMCs decreased in treated subjects compared with controls (P=0.01). Peptide treatment reduced the production of IL-13 by PLA(2)-stimulated PBMCs (P |
| تدمد: | 1365-2222 0954-7894 |
| DOI: | 10.1111/j.1365-2222.2006.02469.x |
| DOI: | 10.1111/j.1365-2222.2006.02469.x⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ce1884c4adc3079cf9afb5b1d65d37 https://doi.org/10.1111/j.1365-2222.2006.02469.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....22ce1884c4adc3079cf9afb5b1d65d37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652222 09547894 |
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| DOI: | 10.1111/j.1365-2222.2006.02469.x |