Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy
| العنوان: | Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy |
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| المؤلفون: | Shijun Zhang, Zhuomao Mo, Wen Ma, Ling Yu, Zhenjie Wang, Binhua Zou, Rui Sun, Yuanyuan Yang, Zhiqiang Yu, Meng Yu |
| المصدر: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2004-2015 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Process of photodynamic therapy, BUN, blood urea nitrogen, Hepatocellular carcinoma, Synergetic delivery, medicine.medical_treatment, CK-MB, creatine kinase-MB, Cr, creatinine, Photodynamic therapy, AST, aspartate aminotransferase, chemistry.chemical_compound, 0302 clinical medicine, So, sorafenib, TUNEL, dT-mediated dUTP Nick-End Labeling, Photosensitizer, DLC, drug loading content, General Pharmacology, Toxicology and Pharmaceutics, DLS, dynamic light scattering, 0303 health sciences, Liposome, LDH, lactate dehydrogenase, Chol, cholesterol, TEM, transmission electron microscope, LP, liposomes, CLSM, confocal laser scanning microscopy, FCM, flow cytometry, Pt, platinum, PDT, photodynamic therapy, 030220 oncology & carcinogenesis, ALT, liver-related alanine aminotransferase, Original Article, RM1-950, DEE, drug encapsulation efficiency, PI, propidium iodide, 03 medical and health sciences, PDXHCC, patient derived tumor xenograft of HCC, ROS, reactive oxygen species, FBS, fetal bovine serum, Dox, doxorubicin, medicine, TP, triptolide, NIR, near-infrared, PDX model, EPR, enhanced permeability and retention, PDX, patient-derived xenograft, 030304 developmental biology, Chemotherapy, DSPG, distearoyl phosphatidylglycerole, Triptolide, Photo-activatable liposomes, Cancer, medicine.disease, BCA, bicinchoninic acid, Ce6, TP/Ce6-LP, liposomes integrated with both photosensitizer Ce6 and chemotherapeutic drug TP, chemistry, Apoptosis, Cancer research, Therapeutics. Pharmacology, HCC, hepatocellular carcinoma, CK, creatine kinase |
| الوصف: | Hepatocellular carcinoma (HCC) has been known as the second common leading cancer worldwide, as it responds poorly to both chemotherapy and medication. Triptolide (TP), a diterpenoid triepoxide, is a promising treatment agent for its effective anticancer effect on multiple cancers including HCC. However, its clinical application has been limited owing to its severe systemic toxicities, low solubility, and fast elimination in the body. Therefore, to overcome the above obstacles, photo-activatable liposomes (LP) integrated with both photosensitizer Ce6 and chemotherapeutic drug TP (TP/Ce6-LP) was designed in the pursuit of controlled drug release and synergetic photodynamic therapy in HCC therapy. The TP encapsulated in liposomes accumulated to the tumor site due to the enhanced permeability and retention (EPR) effect. Under laser irradiation, the photosensitizer Ce6 generated reactive oxygen species (ROS) and further oxidized the unsaturated phospholipids. In this way, the liposomes were destroyed to release TP. TP/Ce6-LP with NIR laser irradiation (TP/Ce6-LP+L) showed the best anti-tumor effect both in vitro and in vivo on a patient derived tumor xenograft of HCC (PDXHCC). TP/Ce6-LP significantly reduced the side effects of TP. Furthermore, TP/Ce6-LP+L induced apoptosis through a caspase-3/PARP signaling pathway. Overall, TP/Ce6-LP+L is a novel potential treatment option in halting HCC progression with attenuated toxicity. Graphical abstract Photo-activatable liposomes incorporating Ce6 and triptolide (TP/Ce6-LP) for hepatocellular carcinoma (HCC) therapy were designed. Photodynamic therapy (PDT) and TP possibly induced cell apoptosis via a caspase-3/PARP signaling pathway in PDXHCC model.Image 1 |
| اللغة: | English |
| تدمد: | 2211-3843 2211-3835 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228ab8ce9785b9f5dd7b0474572f6403 http://europepmc.org/articles/PMC8343191 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....228ab8ce9785b9f5dd7b0474572f6403 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113843 22113835 |
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