Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy
| العنوان: | Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy |
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| المؤلفون: | R. Grobholz, Frank Lohr, Jochen Tuettenberg, Peter Vajkoczy, Marcel Seiz, Marc A. Brockmann, Frederik Wenz |
| المصدر: | Journal of Cancer Research and Clinical Oncology. 135:1239-1244 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Angiogenesis Inhibitors, Internal medicine, Glioma, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Prospective Studies, Survival rate, Aged, Chemotherapy, Temozolomide, Hematology, Brain Neoplasms, business.industry, Cancer, General Medicine, Middle Aged, Prognosis, medicine.disease, Metronomic Chemotherapy, Surgery, Survival Rate, Regimen, Female, Neoplasm Recurrence, Local, Glioblastoma, business, medicine.drug |
| الوصف: | Glioblastoma multiforme is the prototype of an angiogenic tumour. Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy.A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results. |
| تدمد: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-009-0565-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224026d4bb4c5980aeb4befd01c23af7 https://doi.org/10.1007/s00432-009-0565-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....224026d4bb4c5980aeb4befd01c23af7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321335 01715216 |
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| DOI: | 10.1007/s00432-009-0565-9 |