Granulomatous interstitial nephritis secondary to adalimumab therapy
| العنوان: | Granulomatous interstitial nephritis secondary to adalimumab therapy |
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| المؤلفون: | Vicki Sandys, Junaid Qazi, Peter J. Conlon, Brona Moloney, Maurice Barry, Brendan Doyle, Louise Marie Lane, Sean Leavey |
| المصدر: | Clinical Kidney Journal |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 030232 urology & nephrology, medicine.disease_cause, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, medicine, Adalimumab, Adverse effect, 030203 arthritis & rheumatology, Transplantation, Cytokine Therapy, business.industry, Acute kidney injury, medicine.disease, anti-TNF alpha, sarcoid-like granulomatosis, acute kidney injury, Nephrology, Tubulointerstitial Disease, Granuloma, Immunology, dialysis, Secukinumab, business, Nephritis, granulomatis interstitial nephritis, medicine.drug |
| الوصف: | Tumour necrosis factor α (TNF-α) inhibitors are frequently used for the treatment of immune-mediated diseases. Conversely, cytokine therapy has the potential to paradoxically induce autoimmunity. A number of case reports have emerged concerning sarcoid-like granulomatosis secondary to TNF-α therapy, an adverse effect that typically affects the pulmonary and cutaneous systems. Granulomatous interstitial nephritis (GIN) is a relatively unknown, relatively under-reported consequence of adalimumab therapy that can have important clinical implications. To our knowledge, this is the first case report of GIN secondary to anti-TNF-α therapy necessitating a prolonged period of dialysis and the first report demonstrating the successful use of secukinumab as an alternative immunomodulatory agent. |
| اللغة: | English |
| تدمد: | 2048-8513 2048-8505 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f6d758b3e771d18e826b96d02c5c2d http://europepmc.org/articles/PMC5887274 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....20f6d758b3e771d18e826b96d02c5c2d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 20488505 |
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