Urine dicarboxylic acids change in pre-symptomatic Alzheimer’s disease and reflect loss of energy capacity and hippocampal volume
| العنوان: | Urine dicarboxylic acids change in pre-symptomatic Alzheimer’s disease and reflect loss of energy capacity and hippocampal volume |
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| المؤلفون: | Michael G. Harrington, Kevin S. King, Thao Tran, Helena C. Chui, Janice M. Pogoda, S. Shenoi, Alfred N. Fonteh, Sarah P. Edminster, Katherine Castor |
| المصدر: | PLoS ONE, Vol 15, Iss 4, p e0231765 (2020) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Physiology, Disease, Urine, Alzheimer's Disease, Nervous System, Biochemistry, Hippocampus, Diagnostic Radiology, 0302 clinical medicine, Risk Factors, Medicine and Health Sciences, Medicine, Dicarboxylic Acids, Cerebrospinal Fluid, Cognitive Impairment, Aged, 80 and over, education.field_of_study, Multidisciplinary, Cognitive Neurology, Radiology and Imaging, Fatty Acids, Neurodegenerative Diseases, Lipids, Magnetic Resonance Imaging, Body Fluids, Chemistry, Neurology, Physical Sciences, Hippocampal volume, Female, Anatomy, Research Article, medicine.medical_specialty, Lipid accumulation, Amyloid, Imaging Techniques, Cognitive Neuroscience, Science, Population, tau Proteins, Research and Analysis Methods, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, Diagnostic Medicine, Alzheimer Disease, Internal medicine, Mental Health and Psychiatry, Humans, Cognitive Dysfunction, education, Brain function, Aged, Amyloid beta-Peptides, business.industry, Chemical Compounds, Biology and Life Sciences, 030104 developmental biology, Endocrinology, Asymptomatic Diseases, Multivariate Analysis, Csf biomarkers, Cognitive Science, Dementia, business, Acids, Biomarkers, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Non-invasive biomarkers will enable widespread screening and early diagnosis of Alzheimer’s disease (AD). We hypothesized that the considerable loss of brain tissue in AD will result in detection of brain lipid components in urine, and that these will change in concert with CSF and brain biomarkers of AD. We examined urine dicarboxylic acids (DCA) of carbon length 3–10 to reflect products of oxidative damage and energy generation or balance that may account for changes in brain function in AD. Mean C4-C5 DCAs were lower and mean C7-C10 DCAs were higher in the urine from AD compared to cognitively healthy (CH) individuals. Moreover, mean C4-C5 DCAs were lower and mean C7-C9 were higher in urine from CH individuals with abnormal compared to normal CSF amyloid and Tau levels; i.e., the apparent urine changes in AD also appeared to be present in CH individuals that have CSF risk factors of early AD pathology. In examining the relationship between urine DCAs and AD biomarkers, we found short chain DCAs positively correlated with CSF Aβ42, while C7-C10 DCAs negatively correlated with CSF Aβ42 and positively correlated with CSF Tau levels. Furthermore, we found a negative correlation of C7-C10 DCAs with hippocampal volume (p < 0.01), which was not found in the occipital volume. Urine measures of DCAs have an 82% ability to predict cognitively healthy participants with normal CSF amyloid/Tau. These data suggest that urine measures of increased lipoxidation and dysfunctional energy balance reflect early AD pathology from brain and CSF biomarkers. Measures of urine DCAs may contribute to personalized healthcare by indicating AD pathology and may be utilized to explore population wellness or monitor the efficacy of therapies in clinical trials. |
| تدمد: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0231765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20129ffc6a8eb8a711ea1d0e38b263a0 https://doi.org/10.1371/journal.pone.0231765 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....20129ffc6a8eb8a711ea1d0e38b263a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0231765 |