Publisher correction: Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus : A Tensor Imaging Study
| العنوان: | Publisher correction: Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus : A Tensor Imaging Study |
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| المؤلفون: | Ida Blystad, Johan Gasslander, Fredrik Lundin, Andreas Eleftheriou, Anders Tisell |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020) |
| بيانات النشر: | Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Neurologi, lcsh:Medicine, Thalamus, Internal medicine, Neural Pathways, medicine, Humans, lcsh:Science, Postural Balance, Aged, Aged, 80 and over, Cerebral Cortex, Multidisciplinary, business.industry, lcsh:R, Middle Aged, Publisher Correction, White Matter, Hydrocephalus, Normal Pressure, Thalamo cortical, Diffusion Tensor Imaging, Neurology, Case-Control Studies, (Idiopathic) normal pressure hydrocephalus, Cardiology, Anisotropy, lcsh:Q, Female, business, Psychomotor Performance, Diffusion MRI |
| الوصف: | Idiopathic normal pressure hydrocephalus (iNPH) is a disorder with unclear pathophysiology. The diagnosis of iNPH is challenging due to its radiological similarity with other neurodegenerative diseases and ischemic subcortical white matter changes. By using Diffusion Tensor Imaging (DTI) we explored differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in iNPH patients (before and after a shunt surgery) and healthy individuals (HI) and we correlated the clinical results with DTI parameters. Thirteen consecutive iNPH-patients underwent a pre- and post-operative clinical work-up: 10 m walk time (w10mt) steps (w10ms), TUG-time (TUGt) and steps (TUGs); for cognitive function MMSE. Nine HI were included. DTI was performed before and 3 months after surgery, HI underwent DTI once. DTI differences analyzed by manually placing 12 regions-of-interest. In patients motor and balance function improved significantly after surgery (p = 0.01, p = 0.025). Higher nearly significant FA values found in the patients vs HI pre-operatively in the thalamus (p = 0.07) accompanied by an almost significant lower ADC (p = 0.08). Significantly FA and ADC-values were found between patients and HI in FWM (p = 0.02, p = 0.001) and almost significant (p = 0.057) pre- vs postoperatively. Postoperatively we found a trend towards the HIs FA values and a strong significant negative correlation between FA changes vs. gait results in the FWM (r = -0.7, p = 0.008). Our study gives a clear indication of an ongoing pathological process in the periventricular white matter, especially in the thalamus and in the frontal white matter supporting the hypothesis of a shunt reversible thalamo-cortical circuit dysfunction in iNPH. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcfe176c069fe3d066f5324941a0b0f http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174338 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1fcfe176c069fe3d066f5324941a0b0f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |