The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients
| العنوان: | The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients |
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| المؤلفون: | Roman Grytsko, Galyna Bila, Quentin Pagneux, Rabah Boukherroub, Sandor G. Vari, Alexandre Barras, Rostyslav Bilyy, Yuriy Rebets, Markian Samborskyy, Sabine Szunerits, Andrii Rabets |
| المساهمون: | Danylo Halytsky Lviv National Medical University [Lviv, Ukraine], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the Cedars-Sinai Medical Center’s International Research and Innovation in Medicine Program, the Association for Regional Cooperation in the Fieldsof Health, Science and Technology (RECOOP HST Association) RCSS grant 020, and BMYSRG 015, Grant of Ministry of Healthcare of Ukraine 0119U101338 and National Research Foundation of Ukraine 2020.02/0131, Volkswagen-Stiftung grant No 97744. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant agreements No 861878 and 872331. Financial support by ANR project 'nanoMERS' (ANR- 8-CE09-0021) is acknowledged.NeutroCure and NoBiasFluors, ANR-18-CE09-0021,NanoMERS,Utilisation des nanoparticules innovantes pour inhiber les infections à coronavirus(2018), European Project: 9872331(1998) |
| المصدر: | Archivum Immunologiae et Therapiae Experimentalis Archivum Immunologiae et Therapiae Experimentalis, 2021, 69 (1), pp.5. ⟨10.1007/s00005-021-00607-8⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Middle East respiratory syndrome coronavirus, Protein subunit, Short Communication, viruses, Immunology, COVID-9, Immunoglobulins, Peptide, Biology, Cross Reactions, medicine.disease_cause, Antibodies, Viral, Cross-reactivity, Antibodies, 03 medical and health sciences, [SPI]Engineering Sciences [physics], 0302 clinical medicine, medicine, Immunology and Allergy, Humans, Coronavirus, chemistry.chemical_classification, SARS-CoV-2, COVID-19, Convalescence, General Medicine, Virology, 3. Good health, Heptad repeat, chemistry, Severe acute respiratory syndrome-related coronavirus, Polyclonal antibodies, Spike Glycoprotein, Coronavirus, biology.protein, Middle East Respiratory Syndrome Coronavirus, Antibody, 030215 immunology |
| الوصف: | Coronaviruses share conservative spike protein (S) on their enveloped membrane surface, where S1 subunit recognizes and binds the cellular receptor, and the S2 subunit mediates membrane fusion. This similarity raises the question: does coronaviral infection by one create protection to others? Convalescent SARS-CoV-2 (COVID-19) sera were tested for cross reactivity with peptides from Middle East respiratory syndrome coronavirus (MERS-CoV) which shares 74% homology. Our results showed significant cross-reactivity with a peptide of the heptad repeat 2 (HR2) domain of the MERS-CoV spike protein. Sera samples of 47 validated seropositive convalescent COVID-19 patients and 40 sera samples of control patients, collected in pre-COVID time were used to establish cross-bind reactivity with the MERS-CoV peptide. Significantly stronger binding (p |
| اللغة: | English |
| تدمد: | 0004-069X 1661-4917 |
| DOI: | 10.1007/s00005-021-00607-8⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb579e6e1f2d785d19e83b0dd50415d https://hal.science/hal-03542670 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1fb579e6e1f2d785d19e83b0dd50415d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0004069X 16614917 |
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| DOI: | 10.1007/s00005-021-00607-8⟩ |