COVID-19 and Parkinson’s disease: Defects in neurogenesis as the potential cause of olfactory system impairments and anosmia
| العنوان: | COVID-19 and Parkinson’s disease: Defects in neurogenesis as the potential cause of olfactory system impairments and anosmia |
|---|---|
| المؤلفون: | Risna Kanjirassery Radhakrishnan, Harini Sri Rethinavel, Mahesh Kandasamy, Sowbarnika Ravichandran |
| المصدر: | Journal of Chemical Neuroanatomy |
| بيانات النشر: | Elsevier B.V., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Olfactory system, CT, computerized tomography, MCL, mitral cell layer, EPL, external plexiform layer, Review, Olfaction Disorders, 0302 clinical medicine, GBC, globose basal cell, RT-PCR, Real time reverse transcription–polymerase chain reaction, Olfactory bulb dysfunction, COVID-19, coronavirus disease 2019, LB, lewy body, ACE2, angiotensin converting enzyme 2, GG, Grüneberg ganglion, OB, olfactory bulb, Neurogenesis, Dopaminergic, Parkinson Disease, OSN, olfactory sensory neuron, SO, septal organ, ALS, amyotrophic lateral sclerosis, AOS, accessory olfactory system, Neural stem cell, HIV, human immunodeficiency virus, OD, olfactory dysfunction, medicine.anatomical_structure, OR, olfactory receptor, SN, substantia nigra, GCL, granule cell layer, medicine.symptom, GABA, Gamma aminobutyric acid, Anosmia, SVZ, subventricular zone, Olfaction, DDC, dopa decarboxylase, GPCR, G Protein-Coupled Receptor, AD, Alzheimer’s disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, 03 medical and health sciences, Cellular and Molecular Neuroscience, DCX, Doublecortin, GML, glomerular layer, OE, olfactory epithelium, JE, Japanese encephalitis, medicine, RMS, rostral migratory stream, Animals, Humans, NSC, neural stem cells, HBC, Horizontal basal cell, MHV, mouse hepatitis virus, ComputingMethodologies_COMPUTERGRAPHICS, PD, Parkinson’s disease, DAT-SPECT, Dopamine transporter single-photon emission computed tomography, PSA-NCAM, polysialylated-neural cell adhesion molecule, business.industry, COVID-19, IPL, internal plexiform layer, PCNA, Proliferating cell nuclear antigen, Olfactory bulb, HD, Huntington’s disease, 030104 developmental biology, ONL, olfactory nerve layer, Parkinson’s disease, TMPRSS2, transmembrane serine protease 2, MOS, Main olfactory system, DA, dopamine, ORN, olfactory receptor neurons, business, Neuroscience, Olfactory epithelium, MRI, magnetic resonance imaging, 030217 neurology & neurosurgery |
| الوصف: | Graphical abstract Anosmia, a neuropathogenic condition of loss of smell, has been recognized as a key pathogenic hallmark of the current pandemic SARS-CoV-2 infection responsible for COVID-19. While the anosmia resulting from olfactory bulb (OB) pathology is the prominent clinical characteristic of Parkinson's disease (PD), SARS-CoV-2 infection has been predicted as a potential risk factor for developing Parkinsonism-related symptoms in a significant portion of COVID-19 patients and survivors. SARS-CoV-2 infection appears to alter the dopamine system and induce the loss of dopamine neurons that have been known to be the cause of PD. However, the underlying biological basis of anosmia and the potential link between COVID-19 and PD remains obscure. Ample experimental studies in rodents suggest that the occurrence of neural stem cell (NSC) mediated neurogenesis in the OB and olfactory epithelium (OE) is important for olfaction. However, the reports on neurogenesis in the human OB have been a subject of debate, while considerable experimental evidence strongly supports the incidence of neurogenesis in the human OB in adulthood. To note, various viral infections and neuropathogenic conditions including PD with olfactory dysfunctions have been characterized by impaired neurogenesis in OB and OE. Therefore, this article describes and examines the recent reports on SARS-CoV-2 mediated OB dysfunctions and defects in the dopaminergic system responsible for PD. Further, the article emphasizes that COVID-19 and PD associated anosmia could result from the regenerative failure in the replenishment of the dopaminergic neurons in OB and olfactory receptor-expressing neurons in OE respectively. |
| اللغة: | English |
| تدمد: | 1873-6300 0891-0618 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f890db3d2b51cf9084c7c2e5036a9e6 http://europepmc.org/articles/PMC8111887 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1f890db3d2b51cf9084c7c2e5036a9e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18736300 08910618 |
|---|