Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)
| العنوان: | Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene) |
|---|---|
| المؤلفون: | Yujiro Hayashi, Masahiro Yonaga, Kazuhiro Hibino, Yasunobu Matsumoto, Hideaki Kakeya |
| المصدر: | Organic Letters. 18:3382-3385 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Total synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Kinetic resolution, Cascade reaction, Aldol reaction, Physical and Theoretical Chemistry |
| الوصف: | The first total synthesis of RQN-18690A (18-deoxyherboxidiene) and the determination of its absolute stereochemical configuration are described. The synthesis features an organocatalytic aldol reaction for the first step, 1,4- and 1,2- dual reductions of α,β-unsaturated δ-lactone followed by a domino reaction in a one-pot operation, and diastereoselective epoxidation with kinetic resolution. |
| تدمد: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.6b01524 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7072274d233ad2e1a5672ea66576c0 https://doi.org/10.1021/acs.orglett.6b01524 |
| رقم الانضمام: | edsair.doi.dedup.....1f7072274d233ad2e1a5672ea66576c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
|---|---|
| DOI: | 10.1021/acs.orglett.6b01524 |