Pharmacokinetics of isoniazid in children with tuberculosis—A comparative study at two doses
| العنوان: | Pharmacokinetics of isoniazid in children with tuberculosis—A comparative study at two doses |
|---|---|
| المؤلفون: | Sajal Kumar Das, T Kannan, Geetha Ramachandran, A K Hemanth Kumar, Ira Shah, Naman S Shetty |
| المصدر: | Pediatric Pulmonology. 55:660-665 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, Adolescent, Antitubercular Agents, Cmax, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Therapeutic index, Pharmacokinetics, 030225 pediatrics, Internal medicine, Isoniazid, medicine, Humans, heterocyclic compounds, Child, Chromatography, High Pressure Liquid, business.industry, Area under the curve, Infant, medicine.disease, 030228 respiratory system, Area Under Curve, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, medicine.drug |
| الوصف: | AIM To compare the pharmacokinetics of isoniazid (INH) at doses 5 and 10 mg/kg/day. METHODS INH concentrations were estimated by high-performance liquid chromatography in 24 Indian children aged 1 to 15 years on antituberculosis therapy. Blood samples were collected at 0, 2, 4, 6, 8 hours after administration of INH. Patients were randomly given INH at 5 or 10 mg/kg/day and maximum concentrations (Cmax ) and area under the curve (AUC(0-8) ) were determined in each group. The 2-hour concentration of INH was used as Cmax for this study. RESULTS Mean (standard deviation) Cmax was reached in 2 hours and was 2.68 ± 1.19 µg/mL in 5 mg/kg/day group and 8.86 ± 3.94 µg/mL in 10 mg/kg/day group (P |
| تدمد: | 1099-0496 8755-6863 |
| DOI: | 10.1002/ppul.24624 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2a52c4af0c1fd5b20f4171a88ac1a5 https://doi.org/10.1002/ppul.24624 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1f2a52c4af0c1fd5b20f4171a88ac1a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10990496 87556863 |
|---|---|
| DOI: | 10.1002/ppul.24624 |