Cytoreduction with iodine-131-anti-CD33 antibodies before bone marrow transplantation for advanced myeloid leukemias
| العنوان: | Cytoreduction with iodine-131-anti-CD33 antibodies before bone marrow transplantation for advanced myeloid leukemias |
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| المؤلفون: | George Sgouros, Richard J. O'Reilly, David A. Scheinberg, Joseph G. Jurcic, Esperanza B. Papadopoulos, J M Burke, Philip Caron, Chaitanya R. Divgi, Steven M. Larson, K S Panageas, Ronald D. Finn |
| المصدر: | Bone Marrow Transplantation. 32:549-556 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Immunoconjugates, Transplantation Conditioning, Myeloid, Adolescent, Cyclophosphamide, Sialic Acid Binding Ig-like Lectin 3, Antigens, Differentiation, Myelomonocytic, Radiation Dosage, Lintuzumab, Gastroenterology, Iodine Radioisotopes, Antigens, CD, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Transplantation, Homologous, Tissue Distribution, Child, Busulfan, Bone Marrow Transplantation, Preparative Regimen, Transplantation, business.industry, Antibodies, Monoclonal, Myeloid leukemia, Hematology, Middle Aged, medicine.disease, Survival Analysis, Leukemia, Treatment Outcome, medicine.anatomical_structure, Leukemia, Myeloid, Child, Preschool, Immunology, Female, Bone marrow, business, medicine.drug |
| الوصف: | The monoclonal antibodies M195 and HuM195 target CD33, a glycoprotein found on myeloid leukemia cells. When labeled with iodine-131 ((131)I), these antibodies can eliminate large disease burdens and produce prolonged myelosuppression. We studied whether (131)I-labeled M195 and HuM195 could be combined safely with busulfan and cyclophosphamide (BuCy) as conditioning for allogeneic BMT. A total of 31 patients with relapsed/refractory acute myeloloid leukemia (AML) (n=16), accelerated/myeloblastic chronic myeloid leukemia (CML) (n=14), or advanced myelodysplastic syndrome (n=1) received (131)I-M195 or (131)I-HuM195 (122-437 mCi) plus busulfan (16 mg/kg) and cyclophosphamide (90-120 mg/kg) followed by infusion of related-donor bone marrow (27 first BMT; four second BMT). Hyperbilirubinemia was the most common extramedullary toxicity, occurring in 69% of patients during the first 28 days after BMT. Gamma camera imaging showed targeting of the radioisotope to the bone marrow, liver, and spleen, with absorbed radiation doses to the marrow of 272-1470 cGy. The median survival was 4.9 months (range 0.3-90+ months). Three patients with relapsed AML remain in complete remission 59+, 87+, and 90+ months following bone marrow transplantation (BMT). These studies show the feasibility of adding CD33-targeted radioimmunotherapy to a standard BMT preparative regimen; however, randomized trials will be needed to prove a benefit to intensified conditioning with radioimmunotherapy. |
| تدمد: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1704201 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f23cb3c350d12824608aa302589b10b https://doi.org/10.1038/sj.bmt.1704201 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1f23cb3c350d12824608aa302589b10b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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| DOI: | 10.1038/sj.bmt.1704201 |