التفاصيل البيبلوغرافية
| العنوان: |
TERRA biogenesis turnover and implications for function |
| المؤلفون: |
Sascha Feuerhahn, Nahid Iglesias, Antonio Porro, Andrea Panza, Joachim Lingner |
| المصدر: |
FEBS Letters; Vol 584
FEBS Letters |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Yeast Telomeres, Telomerase, RNA, Untranslated, Telomeric repeat-containing RNAs, Transcription, Genetic, Chromosome Ends, Telomeric heterochromatin, Biochemistry, Structural Biology, Heterochromatin, Neoplasms, Mammals, Genetics, 0303 health sciences, 030302 biochemistry & molecular biology, RNA-Binding Proteins, Telomere, Non-coding RNA, Subtelomere, Chromatin, Cell biology, Terra, Transcription, DNA Replication, Cells, Biophysics, Repeat-Containing Rna, Saccharomyces cerevisiae, Biology, Dna Methylation, Chromosomes, 03 medical and health sciences, Saccharomyces-Cerevisiae, Animals, Humans, Messenger-Rna Decay, Molecular Biology, 030304 developmental biology, Quality-Control, Cell Biology, Mammalian Telomeres, Kinetics, Eukaryotic chromosome fine structure, RNA, DNA Damage |
| الوصف: |
Telomeres are heterochromatic structures at the ends of eukaryotic chromosomes. As other heterochromatin regions, telomeres are transcribed, from the subtelomeric region towards chromosome ends into the long non-coding RNA TERRA. Telomere transcription is a widespread phenomenon as it has been observed in species belonging to several kingdoms of the eukaryotic domain. TERRA is part of telomeric heterochromatin in addition to being present in the nucleoplasm. Here, we review the current knowledge of TERRA structure, biogenesis and turnover. In addition, we discuss presumed roles of this RNA during replication of telomeric DNA, heterochromatin formation and the regulation of telomerase. |
| اللغة: |
English |
| تدمد: |
0014-5793 |
| DOI: |
10.1016/j.febslet.2010.07.032 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1de90fec10164029043381e30dfb7b |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....1f1de90fec10164029043381e30dfb7b |
| قاعدة البيانات: |
OpenAIRE |