Intestinal microbiota has important effect on severity of hand foot and mouth disease in children
| العنوان: | Intestinal microbiota has important effect on severity of hand foot and mouth disease in children |
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| المؤلفون: | Jinmin Ma, Xianfeng Wang, Huimin Xia, Huaxin Huang, Minghui Yang, Chenguang Shen, Jing Yuan, Chunxiao Fang, Yi Xu, Fengxia Yang, Rongrong Zou, Hui Wang, Xinfa Wang, Sitang Gong, Yingxia Liu, Yang Yang, Jianmin Li, Jingkai Ji, Fansen Zeng, Yujin Jiang, Jinli Wei, Huanming Yang |
| المصدر: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-16 (2021) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, China, Intestinal microorganisms, Hand foot and mouth disease, Infectious and parasitic diseases, RC109-216, medicine.disease_cause, Predictive markers, Bacteroides and Clostridium, Medical microbiology, stomatognathic system, Genotype, medicine, Enterovirus 71, Bacteroides, Humans, Child, Feces, Enterovirus, biology, business.industry, Incidence (epidemiology), Infant, biology.organism_classification, Enterovirus A, Human, Gastrointestinal Microbiome, Infectious Diseases, Immunology, Cohort, business, Hand, Foot and Mouth Disease, Research Article |
| الوصف: | Background The incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD. Methods We carried out a meta-transcriptomic-wide association study of fecal samples obtained from a cohort of children (254 patients, 227 tested positive for enterovirus, including 16 patients co-infectied with 2 kinds of enterovirus) with mild and severe HFMD and healthy controls. Results We found there was no significant difference in the amount of each virus type between the mild and severe cases. Genes of enterovirus 71 (EV71) and coxsackievirus A (CV-A) from the severe and mild cases did not show significant clustering. Clostridium sp. L2-50 and Bacteroides stercoris ATCC 43183 were enriched in the guts of children with severe HFMD and KEGG enrichment was found between mild and severe cases. Conclusions Intestinal microorganisms appear to interact with enterovirus to determine the progression of HFMD. Genes of Bacteroides and Clostridium may be used as predictive markers for a more efficient prognosis and intervention. The enrichment of intestinal bacteria genes with functions may facilitate the development of severe symptoms for HFMD patients. |
| اللغة: | English |
| تدمد: | 1471-2334 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f06b5772763a1e95542e720aa20f88b https://doaj.org/article/3939a022bc58455c83c9fe824d7d31a0 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1f06b5772763a1e95542e720aa20f88b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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