The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study
| العنوان: | The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study |
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| المؤلفون: | María Ángeles Jiménez-Sousa, Salvador Resino, Ana Zaida Gómez-Moreno, Oscar Brochado-Kith, Daniel Pineda-Tenor, Alicia Gómez-Sanz, Tomas Artaza-Varasa, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez |
| المساهمون: | Instituto de Salud Carlos III |
| المصدر: | Journal of Clinical Medicine Journal of Clinical Medicine; Volume 7; Issue 12; Pages: 473 Journal of Clinical Medicine, Vol 7, Iss 12, p 473 (2018) Repisalud Instituto de Salud Carlos III (ISCIII) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cirrhosis, MERTK, Hepatitis C virus, lcsh:Medicine, Lower risk, medicine.disease_cause, Chronic hepatitis C, Gastroenterology, Article, 03 medical and health sciences, chemistry.chemical_compound, Liver disease, Internal medicine, medicine, chronic hepatitis C, liver stiffness, cirrhosis, SNPs, business.industry, Ribavirin, lcsh:R, General Medicine, Odds ratio, medicine.disease, 030104 developmental biology, chemistry, Transient elastography, business, Liver stiffness |
| الوصف: | BACKGROUND: The myeloid-epithelial-reproductive tyrosine kinase (MERTK) is involved in hepatic steatosis, inflammation, and liver fibrosis. Here we evaluated the association between the MERTK rs4374383 single nucleotide polymorphism (SNP) and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. METHODS: We performed a retrospective study (repeated measures design) in 208 patients who had liver stiffness measurement (LSM), which was assessed using transient elastography. No patient had cirrhosis at baseline (LSM ≥ 12.5 kPa). RESULTS: At baseline, 53.8% were male, the median age was 47.1 years, 13.5% reported a high intake of alcohol, 10.1% were prior injection drug users, 85.3% were infected with HCV genotype 1, and 22.6% had previously failed antiviral therapy (pegylated-interferon-alpha/ribavirin). During a median follow-up of 46.6 months, 26 patients developed cirrhosis. The rs4374383 G carriers had a higher risk of increasing LSM (adjusted arithmetic mean ratio (aAMR) = 1.14; p = 0.006) and a higher likelihood of having an increase in LSM greater than 5 kPa (ΔLSM ≥ 5 kPa) (adjusted odds ratio (aOR) = 2.37; p = 0.029), and greater than 7 kPa (ΔLSM ≥ 7 kPa) (aOR = 3.24; p = 0.032), after controlling for confounding. The SNP's association with cirrhosis progression was close to statistical significance (aOR = 2.18; p = 0.070). CONCLUSIONS: MERTK rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients. This work has been supported by grants given by Instituto de Salud Carlos III (ISCIII) (grant numbers PI14CIII/00011 and PI17CIII/00003 to SR). AFR is also supported by ISCIII (grant numbers CP14CIII/00010). Sí |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df98c88aa577f34e89f4d9f5bf9220e https://hdl.handle.net/20.500.12105/8896 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1df98c88aa577f34e89f4d9f5bf9220e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |