Evidence Suggesting that the Sympathetic Nervous System Mediates Thyroidal Depression in Turpentine-Induced Nonthyroidal Illness Syndrome
| العنوان: | Evidence Suggesting that the Sympathetic Nervous System Mediates Thyroidal Depression in Turpentine-Induced Nonthyroidal Illness Syndrome |
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| المؤلفون: | Daniel P. Cardinali, R. Boado, Angel A. Zaninovich, Héctor E. Chuluyan, Laura F. Cageao, Horacio E. Romeo |
| المصدر: | Neuroendocrinology. 53:360-364 |
| بيانات النشر: | S. Karger AG, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Male, Superior cervical ganglion, medicine.medical_specialty, Sympathetic nervous system, Sympathetic Nervous System, Turpentine, Endocrinology, Diabetes and Metabolism, Thyroid Gland, Thyrotropin, Adrenergic, Norepinephrine, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Internal medicine, Animals, Medicine, Neurotransmitter, Ganglia, Sympathetic, Endocrine and Autonomic Systems, business.industry, Thyroid, Rats, Inbred Strains, medicine.disease, Denervation, Euthyroid Sick Syndromes, Ganglionectomy, Rats, Thyroxine, medicine.anatomical_structure, chemistry, Peripheral nervous system, Cervical ganglia, business, Euthyroid sick syndrome |
| الوصف: | Acute superior cervical ganglionectomy (SCGx) induces in the rat a supraliminal release of neurotransmitter in the innervated tissues (i.e., thyroid gland). This temporary adrenergic hyperactivity is correlated with a significant depression of the thyroid economy resembling the nonthyroidal illness (NTI) syndrome in the rat, and suggest that the sympathetic nervous system may mediate thyroidal changes in NTI. In order to gain further insight into the thyroidal depression in the NTI syndrome, we studied the thyroidal norepinephrine (NE) turnover in turpentine oil (TURP)-induced NTI syndrome and the role of the cervical ganglia (SCG) in the development of NTI in the rat. TURP administration to sham operated rats induced a rapid and significant fall in plasma T4 and TSH levels, in the thyroidal response to exogenous TSH (TIU) and in the thyroidal NE content compared to controls (sham + saline) (T4: 3.1 +/- 0.3 vs. 5.1 +/- 0.6 micrograms/dl, respectively, mean +/- SE, p less than 0.02; TSH: 1.4 +/- 0.4 vs. 4.7 +/- 1.4 ng/ml, respectively, p less than 0.05; TIU: 92 +/- 14 vs. 201 +/- 20 cpm.microliter thyroid/cpm.mg plasma (T/P ratio), respectively, p less than 0.01; thyroidal NE: 680 +/- 20 vs. 761 +/- 29 pg/mg thyroid, respectively, p less than 0.05). The thyroidal turnover rate of NE, however, was significantly increased in TURP-injected rats compared to controls (122 +/- 13 vs. 86 +/- 10 pg/mg/h, respectively, p less than 0.05). TURP injection to chronic SCGx rats induced a similar fall in plasma TSH compared to controls (SCGx + saline) (1.3 +/- 0.2 vs. 4.3 +/- 1.1 ng/ml, respectively, p less than 0.02); plasma T4 and TIU, however, did not change significantly (T4: 3.4 +/- 0.4 vs. 3.7 +/- 0.3 micrograms/dl, respectively, NS; TIU: 172 +/- 8 vs. 226 +/- 27 T/P ratio, respectively, NS).(ABSTRACT TRUNCATED AT 250 WORDS) |
| تدمد: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000125742 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de20704b8a24e0e0102db76929d7c9d https://doi.org/10.1159/000125742 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1de20704b8a24e0e0102db76929d7c9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230194 00283835 |
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| DOI: | 10.1159/000125742 |