Risk factors for hepatocellular carcinoma in catalonia, spain
| العنوان: | Risk factors for hepatocellular carcinoma in catalonia, spain |
|---|---|
| المؤلفون: | F. X. Bosch, Joan Rodés, Josep Costa, Jacques Estève, Xavier Calvet, Conxita Bru, Jordi Bruix, M Vall Mayans, Miquel Bruguera |
| المصدر: | International Journal of Cancer. 46:378-381 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, Cancer Research, medicine.medical_specialty, HBsAg, Carcinoma, Hepatocellular, Cirrhosis, Alcohol Drinking, Population, medicine.disease_cause, Gastroenterology, Risk Factors, Internal medicine, medicine, Humans, Risk factor, education, Aged, Hepatitis B virus, education.field_of_study, biology, business.industry, Liver Neoplasms, Odds ratio, Middle Aged, Hepatitis B, medicine.disease, biology.organism_classification, digestive system diseases, Surgery, Oncology, Hepadnaviridae, Spain, Hepatocellular carcinoma, Female, business, Contraceptives, Oral |
| الوصف: | The influence of hepatitis B virus infection, alcohol consumption, tobacco smoking and use of oral contraceptives on the risk of hepatocellular carcinoma (HCC) was evaluated in a hospital-based case-control study in Catalonia, in the Mediterranean coastal area of north-eastern Spain. A total of 96 HCC cases (86.5% of them with associated liver cirrhosis) and 190 age- and sex-matched controls were studied. The odds ratio of HCC and 95% confidence interval among hepatitis B surface antigen (HBsAg) carriers was 4.9 (1.3-21.9). The OR was not significantly elevated in smokers, and a marginally significant increased risk was found among users of oral contraceptives based on 6 female cases. There was a significant dose-response relationship between alcohol consumption and risk of HCC (chi 2 for trend: 24.3, p less than 0.001). Although hepatitis B infection was strongly associated with HCC, alcohol abuse leading to cirrhosis appears to be one of the main causes of HCC in this region. |
| تدمد: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910460307 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db97412864a8914b623edc23be039b7 https://doi.org/10.1002/ijc.2910460307 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1db97412864a8914b623edc23be039b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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| DOI: | 10.1002/ijc.2910460307 |