CpG methylation in human papillomavirus (HPV) type 31 long control region (LCR) in cervical infections associated with cytological abnormalities
| العنوان: | CpG methylation in human papillomavirus (HPV) type 31 long control region (LCR) in cervical infections associated with cytological abnormalities |
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| المؤلفون: | Levente Szakács, Brigitta László, László Madar, József Kónya, Eszter Gyöngyösi, Anita Szalmás, Annamária Ferenczi, György Veress |
| المصدر: | Virus Genes. 52:552-555 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Uterine Cervical Neoplasms, Cervix Uteri, Genome, Viral, DNA-binding protein, 03 medical and health sciences, 0302 clinical medicine, Transcription (biology), Cell Line, Tumor, Virology, Gene expression, Genetics, Humans, Elméleti orvostudományok, Binding site, Papillomaviridae, Promoter Regions, Genetic, Molecular Biology, Binding Sites, biology, Papillomavirus Infections, Orvostudományok, Oncogene Proteins, Viral, General Medicine, DNA Methylation, biology.organism_classification, Molecular biology, female genital diseases and pregnancy complications, DNA-Binding Proteins, Bisulfite, 030104 developmental biology, CpG site, 030220 oncology & carcinogenesis, DNA, Viral, DNA methylation, CpG Islands, Female |
| الوصف: | The mechanisms that regulate papillomavirus gene expression include DNA methylation. The transcription of papillomavirus oncogenes E6 and E7 is controlled by certain regulatory elements in the LCR, which include binding sites for the E2 protein, a viral regulator of oncogene expression. In HPV-31-infected exfoliated cervical cells, the CpG methylation of the entire LCR was determined by next-generation sequencing after bisulfite modification. Six of the 22 cases had methylated CpG sites in the HPV-31 LCR, including position 7479 and/or 7485, at the promoter distal E2 binding site, thus suggesting a potential regulatory mechanism for papillomavirus transcription. |
| وصف الملف: | application/pdf |
| تدمد: | 1572-994X 0920-8569 |
| DOI: | 10.1007/s11262-016-1338-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d517e776bfaee87eacdbf34b51fa19b https://doi.org/10.1007/s11262-016-1338-6 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1d517e776bfaee87eacdbf34b51fa19b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1572994X 09208569 |
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| DOI: | 10.1007/s11262-016-1338-6 |