Physicochemical properties of β-cyclodextrin solutions and precipitates prepared from injectable vehicles
| العنوان: | Physicochemical properties of β-cyclodextrin solutions and precipitates prepared from injectable vehicles |
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| المؤلفون: | Nutdanai Lertsuphotvanit, Thawatchai Phaechamud, Sai Myo Thurein |
| المصدر: | Asian Journal of Pharmaceutical Sciences, Vol 13, Iss 5, Pp 438-449 (2018) Asian Journal of Pharmaceutical Sciences |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Thermogravimetric analysis, Pharmaceutical Science, Infrared spectroscopy, N-methyl pyrrolidone, 02 engineering and technology, 010402 general chemistry, Precipitates, 01 natural sciences, Matrix (chemical analysis), Matrix formation, chemistry.chemical_compound, Differential scanning calorimetry, 2-Pyrrolidone, Solubility, Pharmacology, chemistry.chemical_classification, Cyclodextrin, Dimethyl sulfoxide, lcsh:RM1-950, 2-pyrrolidone, 021001 nanoscience & nanotechnology, β-CyD solution, 0104 chemical sciences, Original Research Paper, lcsh:Therapeutics. Pharmacology, chemistry, 0210 nano-technology, Nuclear chemistry |
| الوصف: | β-Cyclodextrin (β-CyD) is cyclic oligosaccharide of a glucopyranose, containing a relatively hydrophobic central cavity and hydrophilic outer surface. However, the usefulness of β-CyD is limited owing to its low aqueous solubility whereas we found that its apparent high solubility was evident in some injectable solvents including 2-pyrrolidone (PYR), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO). Therefore, in the present study, the physicochemical properties of the 30–60% w/w β-CyD in PYR, NMP and DMSO were investigated such as viscosity, water resistant, matrix formation rate and syringeability. The higher the concentration of β-CyD resulted in the increased viscosity and the higher force and energy of syringeability. β-CyD in PYR gave the highest viscosity which contributed to the lowest syringeability while β-CyD in DMSO exhibited the highest syringeability. The β-CyD in DMSO and NMP exhibited the higher rate of matrix formation. β-CyD in PYR showed the highest water resistant for phase separation while β-CyD in NMP gave the faster de-mixing rate compared to that from PYR. The difference in physicochemical properties of β-CyD dried ppts studied by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA) revealed that there was partial complexation of β-CyD with respective solvents. Both solution and precipitate characteristic properties will be useful for using β-CyD in further investigation as matrix material dissolved in the injectable vehicles as the in situ forming gel for periodontitis treatment. Graphical abstract The study of characterization of β-CyD ppts gave the prominent differences in physicochemical character from the intact β-CyD which indicated the complexation of β-CyD with respective solvent. The study of the properties of β-CyD solutions supported the potential usage of high concentration of β-CyD in controlled drug delivery systems.Image, graphical abstract |
| تدمد: | 1818-0876 |
| DOI: | 10.1016/j.ajps.2018.02.002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c97d267091e0d78971717a30f60d038 https://doi.org/10.1016/j.ajps.2018.02.002 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1c97d267091e0d78971717a30f60d038 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18180876 |
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| DOI: | 10.1016/j.ajps.2018.02.002 |