Cognitive functioning after epilepsy surgery in children with mild malformation of cortical development and focal cortical dysplasia
| العنوان: | Cognitive functioning after epilepsy surgery in children with mild malformation of cortical development and focal cortical dysplasia |
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| المؤلفون: | Pieter van Eijsden, Kees P.J. Braun, Monique M.J. van Schooneveld, Tim J. Veersema, Angelika Mühlebner, Peter C. van Rijen, Wim G.M. Spliet, Cyrille H. Ferrier, Eleonora Aronica, Peter H. Gosselaar |
| المساهمون: | Pathology, ANS - Cellular & Molecular Mechanisms, APH - Aging & Later Life, APH - Mental Health |
| المصدر: | Epilepsy & Behavior, 94, 209. Academic Press Inc. Epilepsy & behavior, 94, 209-215. Academic Press Inc. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Drug Resistant Epilepsy, Pediatrics, medicine.medical_specialty, Adolescent, Intelligence, Clinical Neurology, Focal cortical dysplasia, Craniofacial Abnormalities, 03 medical and health sciences, Epilepsy, Behavioral Neuroscience, 0302 clinical medicine, Epilepsy surgery, Outcome Assessment, Health Care, medicine, Journal Article, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Cognitive skill, Child, Refractory epilepsy, Intelligence quotient, Mild malformation of cortical development, business.industry, Infant, Cognition, Cortical dysplasia, Malformation of cortical development, medicine.disease, Cognitive test, Malformations of Cortical Development, Neurology, IQ, Child, Preschool, Female, Epilepsies, Partial, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | Mild malformation of cortical development (mMCD) and focal cortical dysplasia (FCD) subtypes combined are by far the most common histological diagnoses in children who undergo surgery as treatment for refractory epilepsy. In patients with refractory epilepsy, a substantial burden of disease is due to cognitive impairment. We studied intelligence quotient (IQ) or developmental quotient (DQ) values and their change after epilepsy surgery in a consecutive series of 42 children (median age at surgery: 4.5, range: 0–17.0 years) with refractory epilepsy due to mMCD/FCD. Cognitive impairment, defined as IQ/DQ below 70, was present in 51% prior to surgery. Cognitive impairment was associated with earlier onset of epilepsy, longer epilepsy duration, and FCD type I histology. Clinically relevant improvement of ≥ 10 IQ/DQ points was found in 24% of children and was related to the presence of presurgical epileptic encephalopathy (EE). At time of postsurgical cognitive testing, 59% of children were completely seizure-free (Engel 1A). We found no association between cognitive outcome and seizure or medication status at two years of follow-up. Epilepsy surgery in children with mMCD or FCD not only is likely to result in complete and continuous seizure freedom, but also improves cognitive function in many. |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 1525-5050 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c69de18ebfc1c6afbff3b8efcb9c9c4 https://dspace.library.uu.nl/handle/1874/387821 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1c69de18ebfc1c6afbff3b8efcb9c9c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15255050 |
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