Dopamine release is enhanced while acetylcholine release is inhibited by nimodipine (Bay e 9736)
| العنوان: | Dopamine release is enhanced while acetylcholine release is inhibited by nimodipine (Bay e 9736) |
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| المؤلفون: | Öie Nordström, Sten Braesch-Andersen, Tamas Bartfai |
| المصدر: | Acta Physiologica Scandinavica. 126:115-119 |
| بيانات النشر: | Wiley, 1986. |
| سنة النشر: | 1986 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Physiology, Dopamine, Stimulation, Internal medicine, medicine, Animals, Nimodipine, Cerebral Cortex, Voltage-dependent calcium channel, Chemistry, Dopaminergic, Nicotinic Acids, Rats, Inbred Strains, Calcium Channel Blockers, Acetylcholine, Corpus Striatum, Electric Stimulation, Rats, Endocrinology, Potassium, Catecholamine, Cholinergic, Calcium, medicine.drug |
| الوصف: | The calcium-channel ligand, nimodipine (Bay e 9736), in submicromolar concentrations (10(-7) to 10(-5) M), enhanced the potassium (25 mM) or electrical stimulation (1 Hz, 1 ms, 180 pulses) evoked release or [3H]dopamine from rat striatal slices, while it inhibited the release of [3H]acetylcholine. Nimodipine had similar effects on slices from the cerebral cortex loaded with [3H]dopamine or [3H]acetylcholine, the electrical stimulation evoked release of the catecholamine was enhanced, while release of [3H]acetylcholine was suppressed. The data indicate that nimodipine may distinguish between Ca2+ channels in dopaminergic and cholinergic nerve-terminals. The simultaneous elevation of dopamine release and suppression of acetylcholine release may prove useful in the treatment of Parkinson's disease. |
| تدمد: | 1365-201X 0001-6772 |
| DOI: | 10.1111/j.1748-1716.1986.tb07794.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c44833723a12a302d88cf41ffa08b69 https://doi.org/10.1111/j.1748-1716.1986.tb07794.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1c44833723a12a302d88cf41ffa08b69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1365201X 00016772 |
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| DOI: | 10.1111/j.1748-1716.1986.tb07794.x |