Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
| العنوان: | Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents |
|---|---|
| المؤلفون: | Rakibe Beklem Bostancıoğlu, Ayşe Tansu Koparal, Mehmet Varol, Kadriye Benkli |
| المساهمون: | BENKLİ, Kadriye, Anadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Benkli, Kadriye, Koparal, Ayşe Tansu, MÜ, Fen Fakültesi, Moleküler Biyoloji Ve Genetik Bölümü, Varol, Mehmet |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Boron Compounds, Organoplatinum Compounds, Angiogenesis, Cell Survival, Health, Toxicology and Mutagenesis, Phenylalanine, Cell Culture Techniques, Antineoplastic Agents, 76410-58-7), 010501 environmental sciences, Toxicology, 01 natural sciences, Umbilical vein, Varol M., Benkli K., Koparal A. T. , Bostancioglu R. B. , -Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents-, DRUG AND CHEMICAL TOXICOLOGY, cilt.42, ss.436-443, 2019, Cisplatin (CAS Number, 03 medical and health sciences, Inhibitory Concentration 50, 0302 clinical medicine, medicine, Human Umbilical Vein Endothelial Cells, Humans, 15663-27-1), Viability assay, Cisplatin (Cas Number, Tumor Stem Cell Assay, 0105 earth and related environmental sciences, Cell Proliferation, Pharmacology, Tube formation, Chemical Health and Safety, Molecular Structure, 4-Dihydroxyborylphenylalanine (Cas Number, Chemistry, Ligand, Public Health, Environmental and Occupational Health, Cancer, General Medicine, medicine.disease, 4-Dihydroxyborylphenylalanine (CAS Number, Combinatorial chemistry, A549 Cells, Drug Design, Cancer cell, 030217 neurology & neurosurgery |
| الوصف: | WOS: 000466854400012 PubMed ID: 30208738 Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4'-dimethyl-2,2'-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton nuclear magnetic resonance, infrared, mass spectrometry, and elemental analyses were utilized for chemical characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacological activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 mu M on A549s and 16.61 mu M on HUVECs; the values for cis-platinum were 5.24 mu M on A549s and 23.14 mu M on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. Anadolu University [1101S019 - AUBAP]; TUBITAK [110S077 - SBAG-HD-560] This study was supported by Anadolu University (Project no: 1101S019 - AUBAP) and TUBITAK (Project no: 110S077 - SBAG-HD-560). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf8e4b223c3bfb89722f2b9f13f1624 https://hdl.handle.net/20.500.12645/599 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1bf8e4b223c3bfb89722f2b9f13f1624 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |