Genome hypermobility by lateral transduction
| العنوان: | Genome hypermobility by lateral transduction |
|---|---|
| المؤلفون: | Nuria Quiles-Puchalt, J. Ross Fitzgerald, Alfredo Fillol-Salom, John Chen, Rodrigo Bacigalupe, Yin Ning Chiang, José R. Penadés, Melissa Su Juan Chee |
| المصدر: | Chen, J, Quiles-Puchalt, N, Chiang, Y N, Bacigalupe, R, Fillo-Salom, A, Chee, M S J, Fitzgerald, J & Penadés, J R 2018, ' Genome hypermobility by lateral transduction ', Science, vol. 362, no. 6411, pp. 207-212 . https://doi.org/10.1126/science.aat5867, https://doi.org/10.1126/science.aat5867, https://doi.org/10.1126/science.aat5867, https://doi.org/10.1126/science.aat5867, https://doi.org/10.1126/science.aat5867, https://doi.org/10.1126/science.aat5867 Science |
| مصطلحات موضوعية: | 0301 basic medicine, Staphylococcus aureus, Prophages, 030106 microbiology, Genetic transduction, Biology, Virus Replication, Genome, 03 medical and health sciences, Transduction (genetics), Transduction, Genetic, evolution, DNA Packaging, phage, gene transfer, Lysogeny, Prophage, Genetics, Multidisciplinary, Chromosome, Chromosomes, Bacterial, transduction, Pathogenicity island, virulence, 030104 developmental biology, Viral replication, Lytic cycle, Virus Activation, Staphylococcus Phages, pathogenicity islands, Genome, Bacterial |
| الوصف: | Pathologizing Staphylococcus , fast Bacteriophages are the main vehicle for gene swapping in bacteria, notoriously of pathogenicity islands and antibiotic resistance genes. Chen et al. noticed that the Staphylococcus aureus prophages do not excise from their host's genome until very late in their life cycles (see the Perspective by Davidson). Thus, the phage DNA is amplified while embedded in the bacterial chromosome. The resulting concatemers are processively packed into virus capsules while still integrated in the host chromosome. Each virion is only set loose when the capsule has reached physical capacity—a process called “headful” packaging. In situ amplification maximizes viral replication, and the headful mechanism means adjacent bacterial-host DNA also gets grabbed to fill the capsule. This process ensures that host genes are transmitted along with the phage. Science , this issue p. 207 ; see also p. 152 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aat5867 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcb058e8377eda8a75ae5928e53f0df |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1bcb058e8377eda8a75ae5928e53f0df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
|---|---|
| DOI: | 10.1126/science.aat5867 |