DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY
| العنوان: | DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY |
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| المؤلفون: | Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Ayaka Hosoki, Ken-ichi Kudo, Daisuke Iizuka, Kento Nagata, Masaru Takabatake, Yukiko Nishimura, Toshiaki Kokubo, Takamitsu Morioka, Kazutaka Doi, Yoshiya Shimada, Shizuko Kakinuma |
| المصدر: | Radiation Protection Dosimetry. 198:1036-1046 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cell Transformation, Neoplastic, Mammary Glands, Animal, Radiation Protection, Radiation, Radiological and Ultrasound Technology, Carcinogenesis, Stem Cells, Public Health, Environmental and Occupational Health, Animals, Female, Radiology, Nuclear Medicine and imaging, General Medicine, Radiation Exposure |
| الوصف: | The uncertain cancer risk of protracted radiation exposure at low dose rates is an important issue in radiological protection. Tissue stem/progenitor cells are a supposed origin of cancer and may contribute to the dose-rate effect on carcinogenesis. The authors have shown that female rats subjected to continuous whole body γ irradiation as juveniles or young adults have a notably reduced incidence of mammary cancer as compared with those irradiated acutely. Experiments using the mammosphere formation assay suggested the presence of radioresistant progenitor cells. Cell sorting indicated that basal progenitor cells in rat mammary gland were more resistant than luminal progenitors to killing by acute radiation, especially at high doses. Thus, the evidence indicates a cell-type-dependent inactivation of mammary cells that manifests only at high acute doses, implying a link to the observed dose-rate effect on carcinogenesis. |
| تدمد: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/ncac050 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba6f57f19455c66fa26845a4a28cc10 https://doi.org/10.1093/rpd/ncac050 |
| Rights: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....1ba6f57f19455c66fa26845a4a28cc10 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17423406 01448420 |
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| DOI: | 10.1093/rpd/ncac050 |