Neuropathological correlates of neuropsychiatric symptoms in dementia
| العنوان: | Neuropathological correlates of neuropsychiatric symptoms in dementia |
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| المؤلفون: | Lucy L, Gibson, Lea T, Grinberg, Dominic, Ffytche, Renata E P, Leite, Roberta D, Rodriguez, Renata E L, Ferretti-Rebustini, Carlos A, Pasqualucci, Ricardo, Nitrini, Wilson, Jacob-Filho, Dag, Aarsland, Claudia K, Suemoto |
| المصدر: | Alzheimer's & Dementia. 19:1372-1382 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology |
| الوصف: | Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood.In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n = 761), Alzheimer's disease (AD; n = 189), LBD (n = 60), and AD+LBD (n = 28).Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant.LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS. |
| تدمد: | 1552-5279 1552-5260 |
| DOI: | 10.1002/alz.12765 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5c9ba31e9b15ca7b1f2873075bb58b https://doi.org/10.1002/alz.12765 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b5c9ba31e9b15ca7b1f2873075bb58b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
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| DOI: | 10.1002/alz.12765 |