Evaluation of the immunomodulatory effect against splenocytes of Balb/c mice of biflorin obtained from Capraria biflora by a new isolation method
| العنوان: | Evaluation of the immunomodulatory effect against splenocytes of Balb/c mice of biflorin obtained from Capraria biflora by a new isolation method |
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| المؤلفون: | Alexandre José da Silva Góes, Mariza S. de Lima Silva, Antonio J. Alves, Jefferson de A. Santos, Beate S. Santos, Cristiane Moutinho Lagos de Melo, Gibson Gomes de Oliveira, Virgínia Maria Barros de Lorena, Rosali Maria Ferreira da Silva |
| المصدر: | Revista Brasileira de Farmacognosia, Vol 29, Iss 4, Pp 464-469 (2019) Revista Brasileira de Farmacognosia, Volume: 29, Issue: 4, Pages: 464-469, Published: 17 OCT 2019 Revista Brasileira de Farmacognosia v.29 n.4 2019 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Immunomodulatory effect, Antioxidant, biology, 010405 organic chemistry, Cell growth, Chemistry, Biological activity, medicine.medical_treatment, lcsh:RS1-441, Pharmacology, Antimicrobial, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, BALB/c, Original method, lcsh:Pharmacy and materia medica, 010404 medicinal & biomolecular chemistry, Immune system, medicine, Splenocyte, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, Biflorin |
| الوصف: | Biflorin (6,9-dimethyl-3-(4-methylpent-3-en-1-yl) benzo[de]chromene-7,8-dione) is a promising substance that has been increasingly studied in the past decades due to its diverse pharmacological properties (i.e. antitumor, antioxidant, antiinflamatory, antimicrobial activity etc.). Aiming the comprehension of its antitumoral activity we investigated the cell proliferation and cytotoxicity habilities of biflorin against mice splenocytes Balb/c. Biflorin was able to stimulate mice splenocytes Balb/c in 48 h of incubation at a concentration of 20.2 μM. Its immunostimulation promoted the production of cytokines such as: TNF-α, IFN-γ, IL-2, IL-6 and IL-17, inducing the immune profile toward a Th1 response. Moreover, an original method which led to an excellent yield with less processing time compared to the methods described in the literature was developed to obtain biflorin, from sawdust of Capraria biflora L., Scrophulariaceae. This method shows a great potential of increasing the production of this pharmacological active compound. Keywords: Biflorin, Original method, Biological activity, Immunomodulatory effect |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b30769fdd193ef57137246d30efcb6d http://www.sciencedirect.com/science/article/pii/S0102695X18304162 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b30769fdd193ef57137246d30efcb6d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |