Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
| العنوان: | Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems |
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| المؤلفون: | Kasim Ozluk, Naciye Isbil-Buyukcoskun, Betul Cam-Etoz |
| المساهمون: | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Çam, Betül Etöz, İşbil, Naciye Büyükcoşkun, Özlük, Kasım, AAH-1692-2021 |
| المصدر: | Brazilian Journal of Medical and Biological Research v.45 n.3 2012 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 45, Iss 3, Pp 250-255 (2012) Brazilian Journal of Medical and Biological Research, Volume: 45, Issue: 3, Pages: 250-255, Published: MAR 2012 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Central Nervous System, Atropine, Vasopressin, (Beta mercapto beta beta cyclopentamethylenepropionyl1, o me tyrosine2,arginine8)vasopressin, Unclassified drug, Blood pressure regulation, Physiology, Vasodilator Agents, Mecamylamine, Biochemistry, Rats, Sprague-Dawley, Nicotinic receptor, Adrenomedullin, Immunoreactivity, Adrenomedullin[22-52], Heart Rate, Receptors, Muscarinic acetylcholine receptor, Mechanisms, Vasopressin derivative, General Pharmacology, Toxicology and Pharmaceutics, lcsh:QH301-705.5, Calcitonin gene related peptide receptor, lcsh:R5-920, Cholinergic stimulation, Arginine vasopressin receptor 1A, General Neuroscience, Muscarinic receptor, Brain, General Medicine, Receptor antagonist, Cholinergic Neurons, Receptor blocking, Peptide, Blood pressure, Female, Calcitonin gene related peptide receptor[8-37], lcsh:Medicine (General), Blood-pressure, Drug mechanism, medicine.drug, medicine.medical_specialty, Consciousness, Vasopressins, medicine.drug_class, Short Communication, Immunology, Research & experimental medicine, Biophysics, Calcitonin gene-related peptide, Article, Vasopressin v1 receptor, Adrenomedullin Receptors, Receptor Activity-Modifying Proteins, Calcitonin Receptor Like Receptor, Internal medicine, medicine, Animals, Animal experiment, Medicine, research & experimental, Biology, Life sciences & biomedicine - other topics, Cardiovascular response, Injections, Intraventricular, Nervous-system, Rattus, business.industry, Drug receptor binding, Antagonist, Cell Biology, Nonhuman, Acetylcholine, Rats, Calcitonin gene related peptide receptor antagonist, Endocrinology, lcsh:Biology (General), Parameters, Rat, Involvement, business, Receptors, Calcitonin Gene-Related Peptide |
| الوصف: | Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V-1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 mu L) caused an increase in both blood pressure and HR (Delta MAP = 11.8 +/- 2.3 mmHg and Delta HR = 39.7 +/- 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP(8-37)) and ADM receptor antagonist (ADM(22-52)) blocked the effect of central ADM on blood pressure and HR. 3) The nicotinic receptor antagonist mecamylamine (25 mu g/10 mu L, icv) and the muscarinic receptor antagonist atropine (5 mu g/10 mu L, icv) prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 mu g/10 mu L, icv). 4) The V-1 receptor antagonist [beta-mercapto-beta-beta-cyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]-vasopressin (V2255; 10 mu g/kg), that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V-1 receptors in the increasing effects of icv ADM on blood pressure and HR. |
| وصف الملف: | text/html; application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0d20d04b7909780ba770c9c8743cbb http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300011 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b0d20d04b7909780ba770c9c8743cbb |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |