Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease
| العنوان: | Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease |
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| المؤلفون: | Victor A.D. Holanda, Adriano Henrique do Nascimento Rangel, Manara B. B. Costa, Edilson D. da Silva, Elaine C. Gavioli, Julia J. Didonet |
| المصدر: | Pharmaceuticals Pharmaceuticals, Vol 14, Iss 775, p 775 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmaceutical Science, neuropeptide S, Substantia nigra, Review, Pharmacology, medicine.disease_cause, Pharmacy and materia medica, Dopamine, Drug Discovery, Neuropeptide S, medicine, oxidative stress, Neuropeptide S receptor, Tyrosine hydroxylase, Pars compacta, business.industry, Dopaminergic, animal models, RS1-441, Parkinson disease, nervous system, Molecular Medicine, Medicine, dopamine, business, Oxidative stress, medicine.drug |
| الوصف: | Parkinson disease (PD) is a neurodegenerative disease mainly characterized by the loss of nigral dopaminergic neurons in the substantia nigra pars compacta. Patients suffering from PD develop severe motor dysfunctions and a myriad of non-motor symptoms. The treatment mainly consists of increasing central dopaminergic neurotransmission and alleviating motor symptoms, thus promoting severe side effects without modifying the disease’s progress. A growing body of evidence suggests a close relationship between neuropeptide S (NPS) and its receptor (NPSR) system in PD: (i) double immunofluorescence labeling studies showed that NPSR is expressed in the nigral tyrosine hydroxylase (TH)-positive neurons; (ii) central administration of NPS increases spontaneous locomotion in naïve rodents; (iii) central administration of NPS ameliorates motor and nonmotor dysfunctions in animal models of PD; (iv) microdialysis studies showed that NPS stimulates dopamine release in naïve and parkinsonian rodents; (v) central injection of NPS decreases oxidative damage to proteins and lipids in the rodent brain; and, (vi) 7 days of central administration of NPS protects from the progressive loss of nigral TH-positive cells in parkinsonian rats. Taken together, the NPS/NPSR system seems to be an emerging therapeutic strategy for alleviating motor and non-motor dysfunctions of PD and, possibly, for slowing disease progress. |
| تدمد: | 1424-8247 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8a5929028795ee1ccf9a4fad4032dd https://pubmed.ncbi.nlm.nih.gov/34451872 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1a8a5929028795ee1ccf9a4fad4032dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14248247 |
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