Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction)
| العنوان: | Quantitative Assessment of the Intracranial Vasculature of Infants and Adults Using iCafe (Intracranial Artery Feature Extraction) |
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| المؤلفون: | Patricia K. Kuhl, Stephen R. Dager, Li Chen, Chun Yuan, Natalia M. Kleinhans, Baocheng Chu, Dennis W. W. Shaw, Jenq-Neng Hwang, Neva M. Corrigan |
| المصدر: | Frontiers in Neurology, Vol 12 (2021) Frontiers in Neurology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Brain development, brain development, Adult age, Magnetic resonance angiography, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Brain laterality, medicine, Quantitative assessment, RC346-429, Original Research, medicine.diagnostic_test, business.industry, magnetic resonance angiography, feature extraction, Intracranial Artery, pediatric vascular disease, Skull, medicine.anatomical_structure, Neurology, Cardiology, Blood supply, Neurology (clinical), Neurology. Diseases of the nervous system, vascular change, business, 030217 neurology & neurosurgery |
| الوصف: | Comprehensive quantification of intracranial artery features may help to assess and understand regional variations of blood supply during early brain development and aging. We analyzed vasculature features of 27 healthy infants during natural sleep, 13 infants at 7-months (7.3 ± 1.0 month), and 14 infants at 12-months (11.7 ± 0.4 month), and 13 older healthy, awake adults (62.8 ± 8.7 years) to investigate age-related vascular differences as a preliminary study of vascular changes associated with brain development. 3D time-of-flight (TOF) magnetic resonance angiography (MRA) acquisitions were processed in iCafe, a technique to quantify arterial features (http://icafe.clatfd.cn), to characterize intracranial vasculature. Overall, adult subjects were found to have increased ACA length, tortuosity, and vasculature density compared to both 7-month-old and 12-month-old infants, as well as MCA length compared to 7-month-old infants. No brain laterality differences were observed for any vascular measures in either infant or adult age groups. Reduced skull and brain sharpness, indicative of increased head motion and brain/vascular pulsation, respectively, were observed in infants but not correlated with length, tortuosity, or vasculature density measures. Quantitative analysis of TOF MRA using iCafe may provide an objective approach for systematic study of infant brain vascular development and for clinical assessment of adult and pediatric brain vascular diseases. |
| اللغة: | English |
| تدمد: | 1664-2295 |
| DOI: | 10.3389/fneur.2021.668298/full |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1982d6a8ba6e5930bba0c393c091781e https://www.frontiersin.org/articles/10.3389/fneur.2021.668298/full |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1982d6a8ba6e5930bba0c393c091781e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642295 |
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| DOI: | 10.3389/fneur.2021.668298/full |