A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI
| العنوان: | A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI |
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| المؤلفون: | Anica Luther, Anne Maass, Paul A. Yushkevich, Emrah Düzel, David Berron, Sandhitsu R. Das, Long Xie, Thomas Wolbers, Laura E.M. Wisse, John Pluta, Paula Vieweg, David A. Wolk, Songlin Ding, A. Hochkeppler |
| المصدر: | NeuroImage : Clinical NeuroImage: Clinical 15, 466-482 (2017). doi:10.1016/j.nicl.2017.05.022 NeuroImage: Clinical, Vol 15, Iss, Pp 466-482 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, physiology [Hippocampus], Hippocampus, AG, Ambient Gyrus, lcsh:RC346-429, methods [Brain Mapping], 0302 clinical medicine, methods [Magnetic Resonance Imaging], Cortex (anatomy), physiology [Dentate Gyrus], Perirhinal cortex, diagnostic imaging [Dentate Gyrus], CSa, anterior, diagnostic imaging [Hippocampus], Brain Mapping, medicine.diagnostic_test, HB, Hippocampal Body, Subiculum, OTS, Occipito-temporal Sulcus, Regular Article, Magnetic Resonance Imaging, Temporal Lobe, CSp, posterior, medicine.anatomical_structure, standards [Brain Mapping], Neurology, PhG, Parahippocampal Gyrus, lcsh:R858-859.7, Female, physiology [Temporal Lobe], Psychology, Adult, DG, Dentate Gyrus, PrC, Perirhinal Cortex, Cognitive Neuroscience, CA3, Cornu Ammonis 3, lcsh:Computer applications to medicine. Medical informatics, Temporal lobe, 03 medical and health sciences, Young Adult, Neuroimaging, CA1, Cornu Ammonis 1, medicine, Humans, Radiology, Nuclear Medicine and imaging, HH, Hippocampal Head, ddc:610, CA2, Cornu Ammonis 2, lcsh:Neurology. Diseases of the nervous system, SaS, Semiannular Sulcus, standards [Magnetic Resonance Imaging], PhC, Parahippocampal Cortex, HT, Hippocampal Tail, Magnetic resonance imaging, MTL, Medial Temporal Lobe, Entorhinal cortex, ErC, Entorhinal Cortex, FG, Fusiform Gyrus, 030104 developmental biology, diagnostic imaging [Temporal Lobe], Sub, Subiculum, SRLM, Stratum radiatum lacunosum-moleculare, Dentate Gyrus, Neurology (clinical), CaS, Calcarine sulcus, CS, Collateral Sulcus, Neuroscience, 030217 neurology & neurosurgery, CSF, Cerebrospinal Fluid |
| الوصف: | Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole structure analyses. Here, we developed a new protocol using 7 Tesla (T) MRI incorporating novel anatomical findings for the manual segmentation of entorhinal cortex (ErC), perirhinal cortex (PrC; divided into area 35 and 36), parahippocampal cortex (PhC), and hippocampus; which includes the subfields subiculum (Sub), CA1, CA2, as well as CA3 and dentate gyrus (DG) which are separated by the endfolial pathway covering most of the long axis of the hippocampus. We provide detailed instructions alongside slice-by-slice segmentations to ease learning for the untrained but also more experienced raters. Twenty-two subjects were scanned (19–32 yrs, mean age = 26 years, 12 females) with a turbo spin echo (TSE) T2-weighted MRI sequence with high-resolution oblique coronal slices oriented orthogonal to the long axis of the hippocampus (in-plane resolution 0.44 × 0.44 mm2) and 1.0 mm slice thickness. The scans were manually delineated by two experienced raters, to assess intra- and inter-rater reliability. The Dice Similarity Index (DSI) was above 0.78 for all regions and the Intraclass Correlation Coefficients (ICC) were between 0.76 to 0.99 both for intra- and inter-rater reliability. In conclusion, this study presents a fine-grained and comprehensive segmentation protocol for MTL structures at 7 T MRI that closely follows recent knowledge from anatomical studies. More specific subdivisions (e.g. area 35 and 36 in PrC, and the separation of DG and CA3) may pave the way for more precise delineations thereby enabling the detection of early volumetric changes in dementia and neuropsychiatric diseases. Highlights • We present a new segmentation protocol for medial temporal lobe subregions at 7 T MRI. • Novel neuroanatomical knowledge from the work of Ding and Van Hoesen is incorporated. • Individual anatomical variability is covered by digitation- and depth-specific rules. • We provide detailed descriptions and slice-by-slice plots to guide the novice rater. • Reliability analyses provide compelling evidence that the rules can be replicated. |
| اللغة: | English |
| تدمد: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2017.05.022 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193f8269c2c67003a0eeb86d0c99142e http://europepmc.org/articles/PMC5476466 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....193f8269c2c67003a0eeb86d0c99142e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2017.05.022 |