Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands
| العنوان: | Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands |
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| المؤلفون: | Manfred Wick, Brigitte Wildemann, Peter Eichhorn, Sven Jarius |
| المصدر: | Fluids and Barriers of the CNS Fluids and Barriers of the CNS, Vol 9, Iss 1, p 14 (2012) |
| بيانات النشر: | BioMed Central, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Oligoclonal bands, Congenital cytomegalovirus infection, Cytomegalovirus, Herpes simplex virus, Intrathecal, medicine.disease_cause, lcsh:RC346-429, Multiple sclerosis, Cellular and Molecular Neuroscience, Cerebrospinal fluid, Developmental Neuroscience, Medicine, Short Paper, lcsh:Neurology. Diseases of the nervous system, Intrathecal IgG synthesis, biology, business.industry, Isoelectric focusing, Rubella virus, General Medicine, medicine.disease, MRZ reaction, Neurology, Measles virus, Varicella zoster virus, Borrelia burgdorferi, Immunology, biology.protein, Antibody, business, Antibody index |
| الوصف: | Background Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis. Findings Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio. Conclusion Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS. |
| اللغة: | English |
| تدمد: | 2045-8118 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193361b5299225a81611a6e91180e758 http://europepmc.org/articles/PMC3487855 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....193361b5299225a81611a6e91180e758 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20458118 |
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