Anti-Microbial Peptides: Strategies of Design and Development and Their Promising Wound-Healing Activities
| العنوان: | Anti-Microbial Peptides: Strategies of Design and Development and Their Promising Wound-Healing Activities |
|---|---|
| المؤلفون: | Fariba Fathi, Maryam Ghobeh, Maryam Tabarzad |
| المصدر: | Molecular Biology Reports. 49:9001-9012 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Structure-Activity Relationship, Wound Healing, Genetics, Computational Biology, General Medicine, Peptides, Molecular Biology, Anti-Bacterial Agents |
| الوصف: | Current approaches used to overcome microbial infections are becoming inefficient due to the overuse or misuse of antibiotics. Antimicrobial peptides (AMPs) are one of the most promising substitutional candidates for commercial antibiotics.The publications in the field of in silico design of AMPs with focus on the wound-healing AMPs were searched though SCOPUS and PubMed. Through publications, it was reported that a number of AMPs approved for clinical use have also showed efficient wound-healing activity. Todays, the design and production of synthetic types of AMPs have attracted attention in order to expand their applications and to cope with their limitations and adverse effects. In this paper, the currently published researches in the field of AMPs and their wound-healing features were summarized and the strategies used in AMPs design and development have been reviewed. Moreover, different databases and online servers used in this regard were summarized.Design and development of active AMPs, especially those with wound-healing activity, can be performed using bioinformatics servers and software, regarding AMPs structure-activity relationships. |
| تدمد: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-022-07405-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930701dd9e492f8c3f96a195b7150e4 https://doi.org/10.1007/s11033-022-07405-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1930701dd9e492f8c3f96a195b7150e4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
|---|---|
| DOI: | 10.1007/s11033-022-07405-1 |