EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
| العنوان: | EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations |
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| المؤلفون: | J. J. M. Van Dongen, Mark Catherwood, Cristiana Bellan, Elke Boone, M. H. Delfau-Larue, Marcel Spaargaren, Lisa Bonello, Frederic Davi, Elizabeth Macintyre, Michael Hummel, R. García Sanz, Anthonie Willem Langerak, A. Håkansson, L. Lombardia, G. I. Carter, Timothy C. Diss, Patricia J. T. A. Groenen, Elizabeth Hodges, Santiago Montes-Moreno, Monika Brüggemann, D. Grand, Hongxiang Liu, Paula Gameiro, BJ Milner, David Gonzalez, Ed Schuuring, Kheira Beldjord, Paul Evans |
| المساهمون: | Immunology |
| المصدر: | Leukemia, 26(10), 2159-2171. Nature Publishing Group Leukemia Leukemia, 26, 2159-71 Leukemia, 26, 10, pp. 2159-71 |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | GAMMA GENE REARRANGEMENTS, ACTION BHM4-CT98-3936, Cancer Research, Translational research Renal disorder [ONCOL 3], Lymphoma, Immunogllin rearrangement, POLYMERASE-CHAIN-REACTION, B-CELL, Receptors, Antigen, T-Cell, Immunoglobulins, Guidelines as Topic, Review, Biology, Guideline, GRADIENT GEL-ELECTROPHORESIS, Receptors, Immunoglobulin, Humans, In patient, Multiplex, T-cell receptor, Gene Rearrangement, Medical screening, Gene rearrangement, DNA, Hematology, T-Cell, Clonality, Lymphoid malignancies, Lymphoproliferative Disorders, Multiplex Polymerase Chain Reaction, Anesthesiology and Pain Medicine, Oncology, Quantitative assay, Antigen, Immunology, CELL RECEPTOR GENES, CONCERTED ACTION BMH4-CT98-3936, Reporting system, FOLLICULAR LYMPHOMA, BIOMED-2 PCR ASSAYS |
| الوصف: | Contains fulltext : 107785.pdf (Publisher’s version ) (Open Access) PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting. Standardization of the pre-analytical and post-analytical phases is now essential to prevent misinterpretation and incorrect conclusions derived from clonality data. As clonality testing is not a quantitative assay, but rather concerns recognition of molecular patterns, guidelines for reliable interpretation and reporting are mandatory. Here, the EuroClonality (BIOMED-2) consortium summarizes important pre- and post-analytical aspects of clonality testing, provides guidelines for interpretation of clonality testing results, and presents a uniform way to report the results of the Ig/TCR assays. Starting from an immunobiological concept, two levels to report Ig/TCR profiles are discerned: the technical description of individual (multiplex) PCR reactions and the overall molecular conclusion for B and T cells. Collectively, the EuroClonality (BIOMED-2) guidelines and consensus reporting system should help to improve the general performance level of clonality assessment and interpretation, which will directly impact on routine clinical management (standardized best-practice) in patients with suspected lymphoproliferations. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0887-6924 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187a22c31442167e3dff4a0bd151b251 http://hdl.handle.net/2318/1532570 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....187a22c31442167e3dff4a0bd151b251 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08876924 |
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