Microvascular oxygen delivery and consumption following treatment with verapamil
| العنوان: | Microvascular oxygen delivery and consumption following treatment with verapamil |
|---|---|
| المؤلفون: | Amy G. Tsai, Nanae Hangai-Hoger, Marcos Intaglietta, Pedro Cabrales, Barbara Friesenecker |
| المصدر: | American Journal of Physiology-Heart and Circulatory Physiology. 288:H1515-H1520 |
| بيانات النشر: | American Physiological Society, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Vasodilator Agents, Oxygene, Hamster, chemistry.chemical_element, Oxygen, Microcirculation, Oxygen Consumption, Cricetinae, Physiology (medical), Internal medicine, medicine, Animals, Distribution (pharmacology), Skin, computer.programming_language, Mesocricetus, Chemistry, Oxygenation, Surgery, Vasodilation, Verapamil, Circulatory system, Cardiology, Cardiology and Cardiovascular Medicine, computer, medicine.drug |
| الوصف: | The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle relaxation to oxygen consumption of the microvascular wall during verapamil-induced vasodilatation. Verapamil HCl delivered in a 0.1 mg/kg bolus injection followed by a continuous infusion of 0.01 mg·kg−1·min−1caused significant arteriolar dilatation, increased microvascular flow and functional capillary density, and decreased arteriolar vessel wall transmural Po2difference. Verapamil caused tissue Po2to increase from 25.5 ± 4.1 mmHg under control condition to 32.0 ± 3.7 mmHg during verapamil treatment. Total oxygen released by the microcirculation to the tissue remained the same as at baseline. Maintenance of the same level of oxygen release to the tissue, increased tissue Po2, and decreased wall oxygen concentration gradient are compatible if vasodilatation significantly lowers vessel wall oxygen consumption, which in this model appears to constitute an important oxygen-consuming compartment. These findings show that treatment with verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation. |
| تدمد: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00955.2004 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1878efbeea52ab88a738242b33f0378e https://doi.org/10.1152/ajpheart.00955.2004 |
| رقم الانضمام: | edsair.doi.dedup.....1878efbeea52ab88a738242b33f0378e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221539 03636135 |
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| DOI: | 10.1152/ajpheart.00955.2004 |