Chikungunya virus-associated encephalitis: A cohort study on La Réunion Island, 2005-2009
| العنوان: | Chikungunya virus-associated encephalitis: A cohort study on La Réunion Island, 2005-2009 |
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| المؤلفون: | Patrick, Gérardin, Thérèse, Couderc, Marc, Bintner, Patrice, Tournebize, Michel, Renouil, Jérome, Lémant, Véronique, Boisson, Gianandrea, Borgherini, Frédérik, Staikowsky, Frédéric, Schramm, Marc, Lecuit, Alain, Michault |
| المساهمون: | Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Centre National de la Recherche Scientifique (CNRS)-IRD-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Centre d'Investigation Clinique de La Réunion - INSERM (CIC 1410), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Henri Mondor, Université de Strasbourg (EA7290), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported by Institut Pasteur, Inserm, ICRES FP7 and LabEx IBEID, Ville de Paris, Fondation BNP Paribas., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Henri Mondor [Créteil], couderc, therese, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID |
| المصدر: | Neurology Neurology, American Academy of Neurology, 2015, ⟨10.1212/WNL.0000000000002234⟩ Neurology, 2015, ⟨10.1212/WNL.0000000000002234⟩ |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Pediatrics, medicine.medical_specialty, Context (language use), medicine.disease_cause, incidence studies, Disease Outbreaks, disease burden, Cohort Studies, 03 medical and health sciences, Case fatality rate, Medicine, viral infections, Humans, Cumulative incidence, Chikungunya, neurological sequelae, Prospective Studies, Aged, Retrospective Studies, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, case fatality rate, business.industry, Infant, Newborn, Outbreak, virus diseases, Infant, Retrospective cohort study, Middle Aged, medicine.disease, encephalopathy, Virology, 3. Good health, 030104 developmental biology, Cohort, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, Encephalitis, Female, Neurology (clinical), prognosis, business, Chikungunya virus, Reunion, Follow-Up Studies |
| الوصف: | International audience; Objectives: To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)-associated Central Nervous System (CNS) disease during the La Réunion outbreak, and assess the disease burden and patient outcome after three years.Methods: CHIKV-associated CNS disease was characterized retrospectively in a cohort of patients with positive CHIKV RT-PCR or anti-CHIKV IgM antibodies in the cerebrospinal fluid and fulfilling International Encephalitis Consortium criteria for encephalitis or encephalopathy. Neurological sequelae were assessed after three years.Results: Between September 2005 and June 2006, 57 patients were diagnosed with CHIKV-associated CNS disease, including 24 with CHIKV-associated encephalitis, the latter corresponding to a CIR of 8.6 per 100,000 persons. Patients with encephalitis were observed at both extremes of age categories. CIR per 100,000 persons were 187 and 37 in patients below 1 year and over 65 years, respectively, both far superior to those of cumulated causes of encephalitis in the USA in these age categories. The case fatality rate of CHIKV-associated encephalitis was 16.6% and the proportion of children discharged with persistent disabilities estimated between 30% and 45%. Beyond the neonatal period, the clinical presentation and outcomes were less severe in infants than in adults.Conclusions: In the context of a large outbreak, CHIKV is a significant cause of CNS disease. As with other etiologies, CHIKV-associated encephalitis case distribution by age follows a U-shaped parabolic curve. |
| وصف الملف: | application/pdf |
| تدمد: | 1526-632X 0028-3878 |
| DOI: | 10.1212/WNL.0000000000002234⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1866d05407aa5b976725da033f37ea81 https://pubmed.ncbi.nlm.nih.gov/27217467 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1866d05407aa5b976725da033f37ea81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
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| DOI: | 10.1212/WNL.0000000000002234⟩ |