أعرض في EDS

Maternal immune activation induces sustained changes in fetal microglia motility

التفاصيل البيبلوغرافية
العنوان: Maternal immune activation induces sustained changes in fetal microglia motility
المؤلفون: Zhongtian Guo, Shouta Sugio, Hideto Yamada, Ako Ikegami, Akari Hashimoto, Kana Ozaki, Tsuyako Tatematsu, Midori Shibushita, Daisuke Kato, Andrew J. Moorhouse, Hiroaki Wake, Koichiro Haruwaka
المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Male, 0301 basic medicine, Science, Motility, Inflammation, Disease, Article, Mice, 03 medical and health sciences, Fetus, 0302 clinical medicine, Glial development, Cell Movement, Pregnancy, medicine, Animals, Multidisciplinary, Microglia, Interleukin-6, business.industry, Brain, Development of the nervous system, Autism spectrum disorders, medicine.disease, Pathophysiology, Mice, Inbred C57BL, Disease Models, Animal, Poly I-C, 030104 developmental biology, medicine.anatomical_structure, Schizophrenia, Prenatal Exposure Delayed Effects, Immunology, Diseases of the nervous system, Medicine, Autism, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Neuroscience
الوصف: Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates this association via effects on the fetal brain, and microglia can respond to maternal immune status, but consensus on how microglia may respond is lacking and no-one has yet examined if microglial process motility is impaired. In this study we investigated how MIA induced at two different gestational ages affected microglial properties at different developmental stages. Immune activation in mid-pregnancy increased IL-6 expression in embryonic microglia, but failed to cause any marked changes in morphology either at E18 or postnatally. In contrast MIA, particularly when induced earlier (at E12), caused sustained alterations in the patterns of microglial process motility and behavioral deficits. Our research has identified an important microglial property that is altered by MIA and which may contribute to the underlying pathophysiological mechanisms linking maternal immune status to subsequent risks for cognitive disease.
وصف الملف: application/pdf
تدمد: 2045-2322
DOI: 10.1038/s41598-020-78294-2
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40
https://doi.org/10.1038/s41598-020-78294-2
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....17c6bc5795db32a984143650c0b88d40
قاعدة البيانات: OpenAIRE
ResultId 1
Header edsair
OpenAIRE
edsair.doi.dedup.....17c6bc5795db32a984143650c0b88d40
845
3

unknown
844.763427734375
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....17c6bc5795db32a984143650c0b88d40&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Maternal immune activation induces sustained changes in fetal microglia motility )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Zhongtian+Guo%22">Zhongtian Guo</searchLink><br /><searchLink fieldCode="AR" term="%22Shouta+Sugio%22">Shouta Sugio</searchLink><br /><searchLink fieldCode="AR" term="%22Hideto+Yamada%22">Hideto Yamada</searchLink><br /><searchLink fieldCode="AR" term="%22Ako+Ikegami%22">Ako Ikegami</searchLink><br /><searchLink fieldCode="AR" term="%22Akari+Hashimoto%22">Akari Hashimoto</searchLink><br /><searchLink fieldCode="AR" term="%22Kana+Ozaki%22">Kana Ozaki</searchLink><br /><searchLink fieldCode="AR" term="%22Tsuyako+Tatematsu%22">Tsuyako Tatematsu</searchLink><br /><searchLink fieldCode="AR" term="%22Midori+Shibushita%22">Midori Shibushita</searchLink><br /><searchLink fieldCode="AR" term="%22Daisuke+Kato%22">Daisuke Kato</searchLink><br /><searchLink fieldCode="AR" term="%22Andrew+J%2E+Moorhouse%22">Andrew J. Moorhouse</searchLink><br /><searchLink fieldCode="AR" term="%22Hiroaki+Wake%22">Hiroaki Wake</searchLink><br /><searchLink fieldCode="AR" term="%22Koichiro+Haruwaka%22">Koichiro Haruwaka</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)<br />Scientific Reports )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Springer Science and Business Media LLC, 2020. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2020 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Science%22">Science</searchLink><br /><searchLink fieldCode="DE" term="%22Motility%22">Motility</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Disease%22">Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Fetus%22">Fetus</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Glial+development%22">Glial development</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Movement%22">Cell Movement</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Multidisciplinary%22">Multidisciplinary</searchLink><br /><searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22business%2Eindustry%22">business.industry</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Development+of+the+nervous+system%22">Development of the nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22Pathophysiology%22">Pathophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%2C+Inbred+C57BL%22">Mice, Inbred C57BL</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink><br /><searchLink fieldCode="DE" term="%22Poly+I-C%22">Poly I-C</searchLink><br /><searchLink fieldCode="DE" term="%22030104+developmental+biology%22">030104 developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+Exposure+Delayed+Effects%22">Prenatal Exposure Delayed Effects</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+nervous+system%22">Diseases of the nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Esymptom%22">medicine.symptom</searchLink><br /><searchLink fieldCode="DE" term="%22business%22">business</searchLink><br /><searchLink fieldCode="DE" term="%22030217+neurology+%26+neurosurgery%22">030217 neurology & neurosurgery</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroscience%22">Neuroscience</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates this association via effects on the fetal brain, and microglia can respond to maternal immune status, but consensus on how microglia may respond is lacking and no-one has yet examined if microglial process motility is impaired. In this study we investigated how MIA induced at two different gestational ages affected microglial properties at different developmental stages. Immune activation in mid-pregnancy increased IL-6 expression in embryonic microglia, but failed to cause any marked changes in morphology either at E18 or postnatally. In contrast MIA, particularly when induced earlier (at E12), caused sustained alterations in the patterns of microglial process motility and behavioral deficits. Our research has identified an important microglial property that is altered by MIA and which may contribute to the underlying pathophysiological mechanisms linking maternal immune status to subsequent risks for cognitive disease. )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 2045-2322 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1038/s41598-020-78294-2 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1038/s41598-020-78294-2" linkWindow="_blank">https://doi.org/10.1038/s41598-020-78294-2</link> )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....17c6bc5795db32a984143650c0b88d40 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1038/s41598-020-78294-2 ) ) [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Male [Type] => general ) [1] => Array ( [SubjectFull] => 0301 basic medicine [Type] => general ) [2] => Array ( [SubjectFull] => Science [Type] => general ) [3] => Array ( [SubjectFull] => Motility [Type] => general ) [4] => Array ( [SubjectFull] => Inflammation [Type] => general ) [5] => Array ( [SubjectFull] => Disease [Type] => general ) [6] => Array ( [SubjectFull] => Article [Type] => general ) [7] => Array ( [SubjectFull] => Mice [Type] => general ) [8] => Array ( [SubjectFull] => 03 medical and health sciences [Type] => general ) [9] => Array ( [SubjectFull] => Fetus [Type] => general ) [10] => Array ( [SubjectFull] => 0302 clinical medicine [Type] => general ) [11] => Array ( [SubjectFull] => Glial development [Type] => general ) [12] => Array ( [SubjectFull] => Cell Movement [Type] => general ) [13] => Array ( [SubjectFull] => Pregnancy [Type] => general ) [14] => Array ( [SubjectFull] => medicine [Type] => general ) [15] => Array ( [SubjectFull] => Animals [Type] => general ) [16] => Array ( [SubjectFull] => Multidisciplinary [Type] => general ) [17] => Array ( [SubjectFull] => Microglia [Type] => general ) [18] => Array ( [SubjectFull] => Interleukin-6 [Type] => general ) [19] => Array ( [SubjectFull] => business.industry [Type] => general ) [20] => Array ( [SubjectFull] => Brain [Type] => general ) [21] => Array ( [SubjectFull] => Development of the nervous system [Type] => general ) [22] => Array ( [SubjectFull] => Autism spectrum disorders [Type] => general ) [23] => Array ( [SubjectFull] => medicine.disease [Type] => general ) [24] => Array ( [SubjectFull] => Pathophysiology [Type] => general ) [25] => Array ( [SubjectFull] => Mice, Inbred C57BL [Type] => general ) [26] => Array ( [SubjectFull] => Disease Models, Animal [Type] => general ) [27] => Array ( [SubjectFull] => Poly I-C [Type] => general ) [28] => Array ( [SubjectFull] => 030104 developmental biology [Type] => general ) [29] => Array ( [SubjectFull] => medicine.anatomical_structure [Type] => general ) [30] => Array ( [SubjectFull] => Schizophrenia [Type] => general ) [31] => Array ( [SubjectFull] => Prenatal Exposure Delayed Effects [Type] => general ) [32] => Array ( [SubjectFull] => Immunology [Type] => general ) [33] => Array ( [SubjectFull] => Diseases of the nervous system [Type] => general ) [34] => Array ( [SubjectFull] => Medicine [Type] => general ) [35] => Array ( [SubjectFull] => Autism [Type] => general ) [36] => Array ( [SubjectFull] => Female [Type] => general ) [37] => Array ( [SubjectFull] => medicine.symptom [Type] => general ) [38] => Array ( [SubjectFull] => business [Type] => general ) [39] => Array ( [SubjectFull] => 030217 neurology & neurosurgery [Type] => general ) [40] => Array ( [SubjectFull] => Neuroscience [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Maternal immune activation induces sustained changes in fetal microglia motility [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Zhongtian Guo ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Shouta Sugio ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hideto Yamada ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ako Ikegami ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Akari Hashimoto ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kana Ozaki ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Tsuyako Tatematsu ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Midori Shibushita ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Daisuke Kato ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Andrew J. Moorhouse ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hiroaki Wake ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Koichiro Haruwaka ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 07 [M] => 12 [Type] => published [Y] => 2020 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 20452322 ) [1] => Array ( [Type] => issn-locals [Value] => edsair ) [2] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 10 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Scientific Reports [Type] => main ) ) ) ) ) ) )
IllustrationInfo