Maternal immune activation induces sustained changes in fetal microglia motility
| العنوان: | Maternal immune activation induces sustained changes in fetal microglia motility |
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| المؤلفون: | Zhongtian Guo, Shouta Sugio, Hideto Yamada, Ako Ikegami, Akari Hashimoto, Kana Ozaki, Tsuyako Tatematsu, Midori Shibushita, Daisuke Kato, Andrew J. Moorhouse, Hiroaki Wake, Koichiro Haruwaka |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Science, Motility, Inflammation, Disease, Article, Mice, 03 medical and health sciences, Fetus, 0302 clinical medicine, Glial development, Cell Movement, Pregnancy, medicine, Animals, Multidisciplinary, Microglia, Interleukin-6, business.industry, Brain, Development of the nervous system, Autism spectrum disorders, medicine.disease, Pathophysiology, Mice, Inbred C57BL, Disease Models, Animal, Poly I-C, 030104 developmental biology, medicine.anatomical_structure, Schizophrenia, Prenatal Exposure Delayed Effects, Immunology, Diseases of the nervous system, Medicine, Autism, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates this association via effects on the fetal brain, and microglia can respond to maternal immune status, but consensus on how microglia may respond is lacking and no-one has yet examined if microglial process motility is impaired. In this study we investigated how MIA induced at two different gestational ages affected microglial properties at different developmental stages. Immune activation in mid-pregnancy increased IL-6 expression in embryonic microglia, but failed to cause any marked changes in morphology either at E18 or postnatally. In contrast MIA, particularly when induced earlier (at E12), caused sustained alterations in the patterns of microglial process motility and behavioral deficits. Our research has identified an important microglial property that is altered by MIA and which may contribute to the underlying pathophysiological mechanisms linking maternal immune status to subsequent risks for cognitive disease. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-78294-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6bc5795db32a984143650c0b88d40 https://doi.org/10.1038/s41598-020-78294-2 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....17c6bc5795db32a984143650c0b88d40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-78294-2 |